![](/images/graphics-bg.png)
Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled Trial
المؤلفون المشاركون
Uransilp, Nattaphol
Muengtaweepongsa, Sombat
Chaiyawatthanananthn, Pannawat
المصدر
Neurology Research International
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Backgrounds.
Stroke is the leading cause of death and long-term disability.
Oxidative stress is elevated during occurrence of acute ischemic stroke (AIS).
Soluble LOX-1 (sLOX-1) and NO are used as biomarkers for vascular oxidative stress that can reflect stabilization of atherosclerotic plaque.
Previous study showed that simvastatin can reduce oxidative stress and LOX-1 expression.
Objectives.
To evaluate neurological outcomes and serum sLOX-1 and NO levels in patients with AIS treatment with low dose 10 mg/day and high dose 40 mg/day of simvastatin.
Methods.
65 patients with AIS within 24 hours after onset were randomized to treatment with simvastatin 10 mg/day or 40 mg/day for 90 days.
Personal data and past history of all patients were recorded at baseline.
The blood chemistries were measured by standard laboratory techniques.
Serum sLOX-1 and NO levels and neurological outcomes including NIHSS, mRS, and Barthel index were tested at baseline and Day 90 after simvastatin therapy.
Results.
Baseline characteristics were not significantly different in both groups except history of hypertension.
Serum sLOX-1 and NO levels significantly reduce in both groups (sLOX-1 = 1.19±0.47 and 0.98±0.37 ng/ml; NO = 49.28±7.21 and 46.59±9.36 μmol/l) in 10 mg/day and 40 mg/day simvastatin groups, respectively.
Neurological outcomes including NIHSS, mRS, and Barthel index significantly improve in both groups.
However, no difference in NO level and neurological outcomes was found at 90 days after treatment as compared between low dose 10 mg/day and high dose 40 mg/day of simvastatin.
Conclusion.
High-dose simvastatin might be helpful to reduce serum sLOX-1.
But no difference in clinical outcomes was found between high- and low-dose simvastatin.
Further more intensive clinical trial is needed to confirm the appropriate dosage of simvastatin in patients with acute ischemic stroke.
This trial is registered with ClinicalTrials.gov ID: NCT03402204.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uransilp, Nattaphol& Chaiyawatthanananthn, Pannawat& Muengtaweepongsa, Sombat. 2018. Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled Trial. Neurology Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1210614
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uransilp, Nattaphol…[et al.]. Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled Trial. Neurology Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1210614
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uransilp, Nattaphol& Chaiyawatthanananthn, Pannawat& Muengtaweepongsa, Sombat. Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patient with Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled Trial. Neurology Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1210614
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210614
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)