Effectiveness and Adverse Effect of Intravenous Lacosamide in Nonconvulsive Status Epilepticus and Acute Repetitive Seizures in Children
المؤلفون المشاركون
Suwanpakdee, Piradee
Ngampoopun, Monsicha
Jaisupa, Nattapon
Nabangchang, Charcrin
المصدر
Neurology Research International
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-10
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Nonconvulsive status epilepticus (NCSE) and acute repetitive seizures (ARS) are associated with significant morbidity and mortality.
Due to the lack of randomized-controlled trials of intravenous antiepileptic drugs (AEDs) in these conditions, trials of a new generation of AEDs in this aspect are needed.
A prospective interventional study was conducted in children under 18 years of age with NCSE or ARS who either had contraindication to or were refractory to first-line AEDs and received intravenous lacosamide.
Demographic data, the efficacy of treatment, and adverse effects were recorded.
Eleven patients with a median age of 11 years, predominantly female (72.7%), were enrolled.
Average loading dose was 227 mg (8.3 mg/kg/dose) and average daily maintenance dose was 249 mg (4.6 mg/kg/dose).
All patients (100%) experienced a reduction in seizure frequency within 24 hours.
Eight of eleven patients (72.7%) experienced a reduction in seizure frequency of more than 50% by the end of the study, and one patient became seizure-free.
In terms of adverse events, one patient had a bradycardia without prolongation of the PR interval.
Interestingly, there was a case of neuronal ceroid lipofuscinosis in which a significant improvement in seizure control was achieved.
The results indicate that intravenous lacosamide may be an alternative treatment for NCSE or ARS in children.
To our knowledge, this is the first study on the use of intravenous lacosamide in Asian children.
This study is registered to Thai Clinical Trials Registry (TCTR) and the trial registration number is TCTR20180508004.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ngampoopun, Monsicha& Suwanpakdee, Piradee& Jaisupa, Nattapon& Nabangchang, Charcrin. 2018. Effectiveness and Adverse Effect of Intravenous Lacosamide in Nonconvulsive Status Epilepticus and Acute Repetitive Seizures in Children. Neurology Research International،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1210621
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ngampoopun, Monsicha…[et al.]. Effectiveness and Adverse Effect of Intravenous Lacosamide in Nonconvulsive Status Epilepticus and Acute Repetitive Seizures in Children. Neurology Research International No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1210621
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ngampoopun, Monsicha& Suwanpakdee, Piradee& Jaisupa, Nattapon& Nabangchang, Charcrin. Effectiveness and Adverse Effect of Intravenous Lacosamide in Nonconvulsive Status Epilepticus and Acute Repetitive Seizures in Children. Neurology Research International. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1210621
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210621
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر