Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile
المؤلفون المشاركون
Budikayanti, Astri
Syeban, Zakiah
Indrawati, Luh Ari
Qadri, Lubna Muhammad
Octaviana, Fitri
المصدر
Neurology Research International
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Introduction.
Adverse events (AEs) associated with antiepileptic drugs (AEDs) affect people with epilepsy’s (PWE) quality of life.
A study conducted in 15 European countries showed that the AEs prevalence of AEDs in PWE was up to 80%.
To date, there are no validated screening instruments to detect AEs of AEDs in Indonesian PWE.
Therefore its epidemiology is currently unknown.
This study aimed to validate the Indonesian version of Liverpool Adverse Events Profile (LAEP), consequently increasing physicians’ awareness toward the probability of AEs and its necessary evaluation.
Furthermore, this study was intended to determine the AEs prevalence of AEDs in Indonesian PWE.
Methods.
The questionnaire was translated from English into Indonesian version.
The validity and reliability were tested using Spearman correlation and Cronbach’s alpha measurement.
An observational cross-sectional study was carried out on consecutive PWE in outpatient clinic, Cipto Mangunkusumo Hospital.
We analyzed duration of epilepsy, onset of epilepsy, seizure frequency, type of epilepsy, etiology and epilepsy syndrome, number of AEDs, duration of AED use, and comorbidity.
Results.
All of the 19 items in the questionnaire were valid, with correlation coefficient ranging from 0.465 to 0.690 (moderate-strong correlation).
Cronbach’s alpha value was 0.846 (good consistency).
The total of 90 subjects were enrolled with 91% screened as having AEs using LAEP questionnaire.
The most common AEs were tiredness (67.8%), sleepiness (66.7%), memory problems (62.2%), and difficulty in concentrating (56.7%).
The only clinical variable that influenced AEs was polytherapy.
Conclusion.
The Indonesian version of LAEP was a valid and reliable instrument to screen AE of AEDs in PWE.
Almost all the subjects in this study were suspected having AEs.
Polytherapy was the independent factor of AE.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Budikayanti, Astri& Qadri, Lubna Muhammad& Syeban, Zakiah& Indrawati, Luh Ari& Octaviana, Fitri. 2018. Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile. Neurology Research International،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1210622
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Budikayanti, Astri…[et al.]. Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile. Neurology Research International No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1210622
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Budikayanti, Astri& Qadri, Lubna Muhammad& Syeban, Zakiah& Indrawati, Luh Ari& Octaviana, Fitri. Adverse Events of Antiepileptic Drugs Using Indonesian Version of Liverpool Adverse Events Profile. Neurology Research International. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1210622
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210622
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر