Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease
المؤلفون المشاركون
Gómez-Serrano, María
Camafeita, Emilio
Loureiro, Marta
Peral, Belén
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-26، 26ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-08
دولة النشر
مصر
عدد الصفحات
26
التخصصات الرئيسية
الملخص EN
Mitochondria are highly dynamic and regulated organelles that historically have been defined based on their crucial role in cell metabolism.
However, they are implicated in a variety of other important functions, making mitochondrial dysfunction an important axis in several pathological contexts.
Despite that conventional biochemical and molecular biology approaches have provided significant insight into mitochondrial functionality, innovative techniques that provide a global view of the mitochondrion are still necessary.
Proteomics fulfils this need by enabling accurate, systems-wide quantitative analysis of protein abundance.
More importantly, redox proteomics approaches offer unique opportunities to tackle oxidative stress, a phenomenon that is intimately linked to aging, cardiovascular disease, and cancer.
In addition, cutting-edge proteomics approaches reveal how proteins exert their functions in complex interaction networks where even subtle alterations stemming from early pathological states can be monitored.
Here, we describe the proteomics approaches that will help to deepen the role of mitochondria in health and disease by assessing not only changes to mitochondrial protein composition but also alterations to their redox state and how protein interaction networks regulate mitochondrial function and dynamics.
This review is aimed at showing the reader how the application of proteomics approaches during the last 20 years has revealed crucial mitochondrial roles in the context of aging, neurodegenerative disorders, metabolic disease, and cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gómez-Serrano, María& Camafeita, Emilio& Loureiro, Marta& Peral, Belén. 2018. Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-26.
https://search.emarefa.net/detail/BIM-1210876
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gómez-Serrano, María…[et al.]. Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-26.
https://search.emarefa.net/detail/BIM-1210876
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gómez-Serrano, María& Camafeita, Emilio& Loureiro, Marta& Peral, Belén. Mitoproteomics: Tackling Mitochondrial Dysfunction in Human Disease. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-26.
https://search.emarefa.net/detail/BIM-1210876
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210876
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر