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Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice
المؤلفون المشاركون
Feryeni, Anwar
Rjeibi, Ilhem
Ncib, Sana
Ben Saad, Anouar
Sdayria, Jazia
Saidi, Issam
Souid, Sami
Allagui, Mohamed Salah
Hfaiedh, Najla
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study was designed to assess the protective effects of Lycium europaeum methanol extract (LEM) on liver and kidney injuries induced by cisplatin.
The phytochemical composition, the antioxidant activity, and hepatorenal injury biomarkers were investigated.
Results revealed that LEM exhibited a significant antioxidant activity in vitro on DPPH radical and H2O2 scavenging assays.
In the animal studies, treatment with LEM significantly reduced the effects of cisplatin intoxication on serum liver biomarkers and serum renal biomarkers.
Meanwhile, LEM diminishes significantly the effect of cisplatin on the level of lipid peroxidation in liver and kidney tissues.
The activities of the antioxidant enzymes (reduced glutathione, glutathione peroxidase, superoxide dismutase, and catalase) were increased in groups pretreated with LEM and quercetin.
Additionally, the normal histological structures of the liver and kidney were restored after treatment with LEM.
This work clearly demonstrated that L.
europaeum may be useful as a drug with hepato-nephroprotective potentials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rjeibi, Ilhem& Feryeni, Anwar& Ben Saad, Anouar& Sdayria, Jazia& Saidi, Issam& Ncib, Sana…[et al.]. 2018. Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rjeibi, Ilhem…[et al.]. Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1210893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rjeibi, Ilhem& Feryeni, Anwar& Ben Saad, Anouar& Sdayria, Jazia& Saidi, Issam& Ncib, Sana…[et al.]. Lycium europaeum Extract: A New Potential Antioxidant Source against Cisplatin-Induced Liver and Kidney Injuries in Mice. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1210893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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