The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro
المؤلفون المشاركون
Yang, Xifei
Zhang, Zai Jun
Liu, Jianjun
Huang, Xinfeng
Zhu, Feiqi
Spencer, Peter S.
Liu, Pan
Chen, Xiao
Zhou, Haizhe
Wang, Liqun
Ren, Xiaohu
Guo, Yi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-02
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD), the most common neurodegenerative disease, has no effective treatment.
Dauricine (DAU), a benzyl tetrahydroisoquinoline alkaloid isolated from the root of Menispermum dauricum DC, reportedly has neuroprotective effects in cerebral ischemia.
Here, we investigated the effects of DAU on N2a cells stably transfected with Swedish mutant amyloid precursor protein (N2a/APP), an AD-like cell model.
ELISA and Western blot analysis revealed that DAU inhibited APP processing and reduced Aβ accumulation.
In addition, DAU ameliorated tau hyperphosphorylation via PP2A, p35/25, and CDK5 pathways in N2a/APP cells.
The amelioration of tau hyperphosphorylation by DAU was also validated in HEK293/Tau cells, another cell line with tau hyperphosphorylation.
Proteomic analysis revealed 85 differentially expressed proteins in the lysates between the wild-type N2a cells (N2a/WT) and the N2a/APP cells in the presence or absence of DAU; these were classified into 6 main categories according to their functions: endoplasmic reticulum (ER) stress-associated proteins, oxidative stress-associated proteins, cytoskeleton proteins, molecular chaperones, mitochondrial respiration and metabolism-related proteins, and signaling proteins.
Taken together, we demonstrated that DAU treatment reduces AD-like pathology, thereby suggesting that DAU has potential therapeutic utility in AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Pan& Chen, Xiao& Zhou, Haizhe& Wang, Liqun& Zhang, Zai Jun& Ren, Xiaohu…[et al.]. 2018. The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1210967
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Pan…[et al.]. The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1210967
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Pan& Chen, Xiao& Zhou, Haizhe& Wang, Liqun& Zhang, Zai Jun& Ren, Xiaohu…[et al.]. The Isoquinoline Alkaloid Dauricine Targets Multiple Molecular Pathways to Ameliorate Alzheimer-Like Pathological Changes In Vitro. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1210967
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1210967
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر