Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines
المؤلفون المشاركون
Arcaro, Carlos Alberto
Assis, Renata Pires
Baviera, Amanda Martins
Brunetti, Iguatemy Lourenço
Ocampos, Fernanda Maria Marins
Barison, Anderson
Miguel, Obdulio Gomes
Moreira, Thais Fernanda
Sorbo, Juliana Maria
Souza, Felipe de Oliveira
Fernandes, Barbara Colatto
de Oliveira, Daniella Maria Soares
Soares, Christiane Pienna
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-03
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
There have been few studies on the pharmacological properties of Rhamnus sphaerosperma var.
pubescens, a native Brazilian species popularly known as “fruto-de-pombo.” The aim of this study was to investigate the scavenging capacity of emodin, physcion, and the ethanolic crude extract of Rhamnus sphaerosperma var.
pubescens against reactive oxygen and nitrogen species, as well as their role and plausible mechanisms in prompting cell death and changes in AKT phosphorylation after cervical (SiHa and C33A) and oral (HSC-3) squamous cell carcinoma treatments.
Emodin was shown to be the best scavenger of NO• and O2•−, while all samples were equally effective in HOCl/OCl− capture.
Emodin, physcion, and the ethanolic extract all exhibited cytotoxic effects on SiHa, C33A, HSC-3, and HaCaT (immortalized human keratinocytes, nontumorigenic cell line), involving mixed cell death (apoptosis and necrosis) independent of the caspase activation pathway.
Emodin, physcion, and the ethanolic extract increased intracellular oxidative stress and DNA damage.
Emodin decreased the activation of AKT in all tumor cells, physcion in HSC-3 and HaCaT cells, and the ethanolic extract in C33A and HaCaT cells, respectively.
The induction of cancer cell death by emodin, physcion, and the ethanolic crude extract of Rhamnus sphaerosperma var.
pubescens was related to an increase in intracellular oxidative stress and DNA damage and a decrease in AKT activation.
These molecules are therefore emerging as interesting candidates for further study as novel options to treat cervical and oral carcinomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moreira, Thais Fernanda& Sorbo, Juliana Maria& Souza, Felipe de Oliveira& Fernandes, Barbara Colatto& Ocampos, Fernanda Maria Marins& de Oliveira, Daniella Maria Soares…[et al.]. 2018. Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1211020
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moreira, Thais Fernanda…[et al.]. Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1211020
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moreira, Thais Fernanda& Sorbo, Juliana Maria& Souza, Felipe de Oliveira& Fernandes, Barbara Colatto& Ocampos, Fernanda Maria Marins& de Oliveira, Daniella Maria Soares…[et al.]. Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1211020
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211020
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر