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Insights on Localized and Systemic Delivery of Redox-Based Therapeutics
المؤلفون المشاركون
Mota, Roberto
Buglak, Nicholas E.
Batrakova, Elena V.
Bahnson, Edward S. M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-14
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
Reactive oxygen and nitrogen species are indispensable in cellular physiology and signaling.
Overproduction of these reactive species or failure to maintain their levels within the physiological range results in cellular redox dysfunction, often termed cellular oxidative stress.
Redox dysfunction in turn is at the molecular basis of disease etiology and progression.
Accordingly, antioxidant intervention to restore redox homeostasis has been pursued as a therapeutic strategy for cardiovascular disease, cancer, and neurodegenerative disorders among many others.
Despite preliminary success in cellular and animal models, redox-based interventions have virtually been ineffective in clinical trials.
We propose the fundamental reason for their failure is a flawed delivery approach.
Namely, systemic delivery for a geographically local disease limits the effectiveness of the antioxidant.
We take a critical look at the literature and evaluate successful and unsuccessful approaches to translation of redox intervention to the clinical arena, including dose, patient selection, and delivery approach.
We argue that when interpreting a failed antioxidant-based clinical trial, it is crucial to take into account these variables and importantly, whether the drug had an effect on the redox status.
Finally, we propose that local and targeted delivery hold promise to translate redox-based therapies from the bench to the bedside.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Buglak, Nicholas E.& Batrakova, Elena V.& Mota, Roberto& Bahnson, Edward S. M.. 2018. Insights on Localized and Systemic Delivery of Redox-Based Therapeutics. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1211042
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Buglak, Nicholas E.…[et al.]. Insights on Localized and Systemic Delivery of Redox-Based Therapeutics. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-23.
https://search.emarefa.net/detail/BIM-1211042
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Buglak, Nicholas E.& Batrakova, Elena V.& Mota, Roberto& Bahnson, Edward S. M.. Insights on Localized and Systemic Delivery of Redox-Based Therapeutics. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1211042
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211042
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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