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Superoxide Anion Production and Bioenergetic Profile in Young and Elderly Human Primary Myoblasts
المؤلفون المشاركون
Guarnieri, Simone
Marrone, Mariangela
La Rovere, Rita Maria Laura
Di Filippo, Ester Sara
Monaco, Giovanni
Pietrangelo, Tiziana
Bultynck, Geert
Fulle, Stefania
Mancinelli, Rosa
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-24
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Sarcopenia is the age-related loss of skeletal muscle mass, strength, and function.
It is associated with regenerative difficulties by satellite cells, adult muscle stem cells, and alteration of oxidative management, mainly the increase in superoxide anions (O2•−).
We aimed to investigate the relation between regenerative deficit in elderly and increase in O2•− production along with mitochondrial alterations.
Myoblasts and myotubes from skeletal muscle of young and elderly healthy subjects (27.8 ± 6 and 72.4 ± 6.5 years old) were measured: (1) superoxide dismutase activity and protein content, (2) mitochondrial O2•− production levels, (3) O2•− production variability, and (4) mitochondrial bioenergetic profile.
Compared to young myoblasts, elderly myoblasts displayed decreased SOD2 protein expression, elevated mitochondrial O2•− baseline levels, and decreased oxidative phosphorylation and glycolysis.
Additionally, elderly versus young myotubes showed elevated mitochondrial O2•− levels when stressed with N-acetyl cysteine or high glucose and higher glycolysis despite showing comparable oxidative phosphorylation levels.
Altogether, the elderly may have less metabolic plasticity due to the impaired mitochondrial function caused by O2•−.
However, the increased energy demand related to the differentiation process appears to activate compensatory mechanisms for the partial mitochondrial dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marrone, Mariangela& La Rovere, Rita Maria Laura& Guarnieri, Simone& Di Filippo, Ester Sara& Monaco, Giovanni& Pietrangelo, Tiziana…[et al.]. 2018. Superoxide Anion Production and Bioenergetic Profile in Young and Elderly Human Primary Myoblasts. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211067
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marrone, Mariangela…[et al.]. Superoxide Anion Production and Bioenergetic Profile in Young and Elderly Human Primary Myoblasts. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1211067
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marrone, Mariangela& La Rovere, Rita Maria Laura& Guarnieri, Simone& Di Filippo, Ester Sara& Monaco, Giovanni& Pietrangelo, Tiziana…[et al.]. Superoxide Anion Production and Bioenergetic Profile in Young and Elderly Human Primary Myoblasts. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211067
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211067
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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