Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link

المؤلفون المشاركون

Zhang, Yukun
Wang, Changyuan
Jin, Yue
Yang, Qining
Meng, Qiang
Liu, Qi
Dai, Yongguo
Cai, Lifei
Liu, Zhihao
Liu, Kexin
Sun, Huijun

المصدر

Oxidative Medicine and Cellular Longevity

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-06-25

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الأحياء

الملخص EN

Catalpol, an iridoid glucoside, has been found present in large quantities in the root of Rehmannia glutinosa L.

and showed a strong antioxidant capacity in the previous study.

In the present work, the protective effect of catalpol against AS via inhibiting oxidative stress, DNA damage, and telomere shortening was found in LDLr−/− mice.

This study also shows that activation of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)/telomerase reverse transcriptase (TERT) pathway, which is the new link between mitochondria and telomere, was involved in the protective effects of catalpol.

Further, by using PGC-1α or TERT siRNA in oxLDL-treated macrophages, it is proved that catalpol reduced oxidative stress, telomere function, and related DNA damage at least partly through activating the PGC-1α/TERT pathway.

Moreover, dual luciferase activity assay-validated catalpol directly enhanced PGC-1α promoter activity.

In conclusion, our study revealed that the PGC-1α/TERT pathway might be a possible therapeutic target in AS and catalpol has highly favorable characteristics for the treatment of AS via modulating this pathway.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Yukun& Wang, Changyuan& Jin, Yue& Yang, Qining& Meng, Qiang& Liu, Qi…[et al.]. 2018. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211115

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Yukun…[et al.]. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1211115

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Yukun& Wang, Changyuan& Jin, Yue& Yang, Qining& Meng, Qiang& Liu, Qi…[et al.]. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211115

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1211115