Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link

Joint Authors

Zhang, Yukun
Wang, Changyuan
Jin, Yue
Yang, Qining
Meng, Qiang
Liu, Qi
Dai, Yongguo
Cai, Lifei
Liu, Zhihao
Liu, Kexin
Sun, Huijun

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-06-25

Country of Publication

Egypt

No. of Pages

16

Main Subjects

Biology

Abstract EN

Catalpol, an iridoid glucoside, has been found present in large quantities in the root of Rehmannia glutinosa L.

and showed a strong antioxidant capacity in the previous study.

In the present work, the protective effect of catalpol against AS via inhibiting oxidative stress, DNA damage, and telomere shortening was found in LDLr−/− mice.

This study also shows that activation of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)/telomerase reverse transcriptase (TERT) pathway, which is the new link between mitochondria and telomere, was involved in the protective effects of catalpol.

Further, by using PGC-1α or TERT siRNA in oxLDL-treated macrophages, it is proved that catalpol reduced oxidative stress, telomere function, and related DNA damage at least partly through activating the PGC-1α/TERT pathway.

Moreover, dual luciferase activity assay-validated catalpol directly enhanced PGC-1α promoter activity.

In conclusion, our study revealed that the PGC-1α/TERT pathway might be a possible therapeutic target in AS and catalpol has highly favorable characteristics for the treatment of AS via modulating this pathway.

American Psychological Association (APA)

Zhang, Yukun& Wang, Changyuan& Jin, Yue& Yang, Qining& Meng, Qiang& Liu, Qi…[et al.]. 2018. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211115

Modern Language Association (MLA)

Zhang, Yukun…[et al.]. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1211115

American Medical Association (AMA)

Zhang, Yukun& Wang, Changyuan& Jin, Yue& Yang, Qining& Meng, Qiang& Liu, Qi…[et al.]. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211115

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1211115