Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link
Joint Authors
Zhang, Yukun
Wang, Changyuan
Jin, Yue
Yang, Qining
Meng, Qiang
Liu, Qi
Dai, Yongguo
Cai, Lifei
Liu, Zhihao
Liu, Kexin
Sun, Huijun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-25
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Catalpol, an iridoid glucoside, has been found present in large quantities in the root of Rehmannia glutinosa L.
and showed a strong antioxidant capacity in the previous study.
In the present work, the protective effect of catalpol against AS via inhibiting oxidative stress, DNA damage, and telomere shortening was found in LDLr−/− mice.
This study also shows that activation of the peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α)/telomerase reverse transcriptase (TERT) pathway, which is the new link between mitochondria and telomere, was involved in the protective effects of catalpol.
Further, by using PGC-1α or TERT siRNA in oxLDL-treated macrophages, it is proved that catalpol reduced oxidative stress, telomere function, and related DNA damage at least partly through activating the PGC-1α/TERT pathway.
Moreover, dual luciferase activity assay-validated catalpol directly enhanced PGC-1α promoter activity.
In conclusion, our study revealed that the PGC-1α/TERT pathway might be a possible therapeutic target in AS and catalpol has highly favorable characteristics for the treatment of AS via modulating this pathway.
American Psychological Association (APA)
Zhang, Yukun& Wang, Changyuan& Jin, Yue& Yang, Qining& Meng, Qiang& Liu, Qi…[et al.]. 2018. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211115
Modern Language Association (MLA)
Zhang, Yukun…[et al.]. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1211115
American Medical Association (AMA)
Zhang, Yukun& Wang, Changyuan& Jin, Yue& Yang, Qining& Meng, Qiang& Liu, Qi…[et al.]. Activating the PGC-1αTERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1211115
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1211115