Exercise-Induced Reductive Stress Is a Protective Mechanism against Oxidative Stress in Peripheral Blood Mononuclear Cells
المؤلفون المشاركون
Veskoukis, Aristidis S.
Kouretas, Dimitrios
Deli, Chariklia K.
Jamurtas, Athanasios Z.
Priftis, Alexandros
Spanidis, Ypatios
Stagos, Dimitrios
Papanikolaou, Christina
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Eccentric exercise is a well-studied modality that induces oxidative stress and muscle damage.
Furthermore, it promotes inflammatory response in which peripheral blood mononuclear cells (PBMCs) are the major mediators.
Although free radicals are necessary in a specific range of concentrations, yet unknown, it remains unclear whether reductive redox status (i.e., increased antioxidant defenses and impaired free radical generation) is beneficial or not.
Thus, the aim of the present investigation was to examine the effects of reductive stress and the impact of reduced glutathione (GSH) baseline values on the ability of PBMCs to counteract oxidative stress induced by a potent oxidative agent.
PBMCs were isolated from the blood of subjects who performed eccentric exercise and treated with t-BOOH for 24 h.
The subjects were clustered in the reductive and the oxidative group on the basis of increased or decreased GSH concentration postexercise compared to preexercise values, respectively.
According to our results in PBMCs, lipid peroxidation levels as depicted by thiobarbituric acid reactive substances (TBARS) remained unchanged in the reductive group contrary to the observed enhancement in the oxidative group.
In addition, GSH concentration and catalase activity increased in the reductive group, whereas they were not affected in the oxidative group.
In conclusion, the effects of an oxidizing agent on the redox status of PBMCs isolated from the blood of athletes after acute eccentric exercise are dependent on the baseline values of GSH in erythrocytes.
Otherwise, reductive stress defined by increased GSH levels is a protective mechanism, at least when followed by an oxidative stimulus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Spanidis, Ypatios& Veskoukis, Aristidis S.& Papanikolaou, Christina& Stagos, Dimitrios& Priftis, Alexandros& Deli, Chariklia K.…[et al.]. 2018. Exercise-Induced Reductive Stress Is a Protective Mechanism against Oxidative Stress in Peripheral Blood Mononuclear Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211141
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Spanidis, Ypatios…[et al.]. Exercise-Induced Reductive Stress Is a Protective Mechanism against Oxidative Stress in Peripheral Blood Mononuclear Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211141
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Spanidis, Ypatios& Veskoukis, Aristidis S.& Papanikolaou, Christina& Stagos, Dimitrios& Priftis, Alexandros& Deli, Chariklia K.…[et al.]. Exercise-Induced Reductive Stress Is a Protective Mechanism against Oxidative Stress in Peripheral Blood Mononuclear Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211141
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211141
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر