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TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance
المؤلفون المشاركون
Wu, Bang-wei
Li, Jian
Ni, Huanchun
Zhuang, Xinyu
Qi, Zhiyong
Chen, Qiying
Wen, Zhichao
Shi, Haiming
Luo, Xinping
Jin, Bo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-26
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Mitochondrial dynamic imbalance associates with several cardiovascular diseases.
However, the role of mitochondrial dynamics in TLR4 activation-mediated dilated cardiomyopathy (DCM) progress remains unknown.
A model of experimental autoimmune myocarditis (EAM) was established in BALB/c mice on which TLR4 activation by LPS-EB or TLR4 inhibition by LPS-RS was performed to induce chronic inflammation for 5 weeks.
TLR4 activation promoted the transition of EAM to DCM as demonstrated by increased cardiomyocyte apoptosis, myocardial fibrosis, ventricular dilatation, and declined heart function.
TLR4 inhibition mitigated the above DCM changes.
Transmission electron microscope study showed that mitochondria became fragmented, also with damaged crista in ultrastructure in EAM mice.
TLR4 activation aggravated the above mitochondrial aberration, and TLR4 inhibition alleviated it.
The mitochondrial dynamic imbalance and damage in DCM development were mainly associated with OPA1 downregulation, which may be caused by elevated TNF-α level and ROS stress after TLR4 activation.
Furthermore, OMA1/YME1L abnormal degradation was involved in the OPA1 dysfunction, and intervening OMA1/YME1L in H9C2 significantly alleviated mitochondrial fission, ultrastructure damage, and cell apoptosis induced by TNF-α and ROS.
These data indicate that TLR4 activation resulted in OPA1 dysfunction, promoting mitochondrial dynamic imbalance and damage, which may involve in the progress of EAM to DCM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Bang-wei& Li, Jian& Ni, Huanchun& Zhuang, Xinyu& Qi, Zhiyong& Chen, Qiying…[et al.]. 2018. TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211185
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Bang-wei…[et al.]. TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1211185
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Bang-wei& Li, Jian& Ni, Huanchun& Zhuang, Xinyu& Qi, Zhiyong& Chen, Qiying…[et al.]. TLR4 Activation Promotes the Progression of Experimental Autoimmune Myocarditis to Dilated Cardiomyopathy by Inducing Mitochondrial Dynamic Imbalance. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211185
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211185
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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