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The Exposure of Phosphatidylserine Influences Procoagulant Activity in Retinal Vein Occlusion by Microparticles, Blood Cells, and Endothelium
المؤلفون المشاركون
Dong, Zengxiang
Su, Ying
Deng, Xueqing
Ma, Ruishuang
Wang, Feng
Shi, Jialan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The pathogenesis of hypercoagulability in retinal vein occlusion (RVO) is largely unknown.
Whether the exposure of phosphatidylserine (PS) and microparticle (MPs) release will affect procoagulant activity (PCA) in RVO needs to be investigated.
Objectives.
To evaluate PS expression, circulating MPs, and the corresponding PCA in RVO patients.
Twenty-five RVO patients were compared with 25 controls.
PS-positive cells were detected by flow cytometry.
Cell-specific MPs were measured by lactadherin for PS and relevant CD antibody.
We explored PCA with coagulation time, purified coagulation complex assays, and fibrin production assays.
In RVO, MPs from platelets, erythrocytes, leukocyte, and endothelial cells were increased and the exposure of PS was elevated significantly when compared with controls.
In addition, we showed that circulating MPs in RVO patients were mostly derived from platelets, representing about 60–70% of all MPs, followed by erythrocytes and leukocytes.
Moreover, PS exposure, ECs, and MPs in RVO lead to shortened clotting time with upregulation of FXa and thrombin formation obviously.
Importantly, ECs treated with RVO serum which bounded FVa and FXa explicitly suggested the damage of retinal vein endothelial cells.
Furthermore, lactadherin can inhibit the combination between PS and coagulation factors by approximately 70% and then exert an anticoagulant effect.
In summary, circulating MPs and exposed PS from different cells may contribute to the increased PCA in patients with RVO.
Lactadherin can be used for PS detection and an anticoagulant agent.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Ying& Deng, Xueqing& Ma, Ruishuang& Dong, Zengxiang& Wang, Feng& Shi, Jialan. 2018. The Exposure of Phosphatidylserine Influences Procoagulant Activity in Retinal Vein Occlusion by Microparticles, Blood Cells, and Endothelium. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211282
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Ying…[et al.]. The Exposure of Phosphatidylserine Influences Procoagulant Activity in Retinal Vein Occlusion by Microparticles, Blood Cells, and Endothelium. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211282
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Ying& Deng, Xueqing& Ma, Ruishuang& Dong, Zengxiang& Wang, Feng& Shi, Jialan. The Exposure of Phosphatidylserine Influences Procoagulant Activity in Retinal Vein Occlusion by Microparticles, Blood Cells, and Endothelium. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211282
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211282
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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