Association of Impaired Reactive Aldehyde Metabolism with Delayed Graft Function in Human Kidney Transplantation
المؤلفون المشاركون
Gross, Eric R.
Wijermars, Leonie G. M.
Schaapherder, Alexander F.
George, Thomas
Sinharoy, Pritam
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Delayed graft function is an early complication following kidney transplantation with an unclear molecular mechanism.
Here we determined whether impaired reactive aldehyde metabolism is associated with delayed graft function.
Human kidney biopsies from grafts with delayed graft function were compared with grafts that did not develop delayed graft function by Ingenuity gene pathway analysis.
A second series of grafts with delayed graft function (n=10) were compared to grafts that did not develop delayed graft function (n=10) by measuring reactive aldehyde metabolism, reactive aldehyde-induced protein adduct formation, and aldehyde dehydrogenase (ALDH) gene and protein expression.
In the first series of kidney biopsies, several gene families known for metabolizing reactive aldehydes, such as aldehyde dehydrogenase (ALDH), aldo-keto reductase (AKR), and glutathione-S transferase (GSTA), were upregulated in kidneys that did not develop delayed graft function versus those that did.
In the second series of kidney grafts, we focused on measuring aldehyde-induced protein adducts and ALDH enzymatic activity.
The reactive aldehyde metabolism by ALDH enzymes was reduced in kidneys with delayed graft function compared to those that did not (37 ± 12∗ vs.
79 ± 5 μg/min/mg tissue, ∗P<0.005, respectively).
ALDH enzymatic activity was also negatively correlated with length of hospital stay after a kidney transplant.
Together, our study identifies a reduced ALDH enzymatic activity with kidneys developing delayed graft function compared to those that did not.
Measuring ALDH enzymatic activity and reactive aldehyde-induced protein adducts can potentially be further developed as a biomarker to assess for delayed graft function and recovery from a kidney transplant.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wijermars, Leonie G. M.& Schaapherder, Alexander F.& George, Thomas& Sinharoy, Pritam& Gross, Eric R.. 2018. Association of Impaired Reactive Aldehyde Metabolism with Delayed Graft Function in Human Kidney Transplantation. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211288
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wijermars, Leonie G. M.…[et al.]. Association of Impaired Reactive Aldehyde Metabolism with Delayed Graft Function in Human Kidney Transplantation. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211288
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wijermars, Leonie G. M.& Schaapherder, Alexander F.& George, Thomas& Sinharoy, Pritam& Gross, Eric R.. Association of Impaired Reactive Aldehyde Metabolism with Delayed Graft Function in Human Kidney Transplantation. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211288
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211288
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر