ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells
المؤلفون المشاركون
Zhang-Akiyama, Qiu-Mei
Moriwaki, Takahito
Yamasaki, Akira
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Introduction.
Ataxia-telangiectasia-mutated (ATM) kinase is a master regulator of the DNA damage response and is directly activated by reactive oxygen species (ROSs) in addition to DNA double-stranded breaks.
However, the physiological function of the response to ROSs is not understood.
Purpose.
In the present study, we investigated how ATM responds to ROSs in Caenorhabditis elegans (C.
elegans).
Materials and Methods.
First, we measured sensitivities of larvae to DNA-damaging agents and ROSs.
Next, we analyzed the drug sensitivities of fully matured adult worms, which consist of nondividing somatic cells.
Dead cell staining with acridine orange was performed to visualize the dead cells.
In addition, we performed GFP reporter assays of lgg-1, an autophagy-related gene, to determine the types of cell death.
Results.
atm-1(tm5027) larvae showed a wide range of sensitivities to both DNA-damaging agents and ROSs.
In contrast, fully matured adult worms, which consist of nondividing somatic cells, showed sensitivity to DNA-damaging agent, NaHSO3, but they showed resistance to H2O2.
Dead cell staining and GFP reporter assays of lgg-1 suggest that C.
elegans ATM-1 induces the cell death with autophagy in intestinal cells in response to H2O2.
Conclusion.
We revealed that ATM induces cell death in response to H2O2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moriwaki, Takahito& Yamasaki, Akira& Zhang-Akiyama, Qiu-Mei. 2018. ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211321
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moriwaki, Takahito…[et al.]. ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211321
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moriwaki, Takahito& Yamasaki, Akira& Zhang-Akiyama, Qiu-Mei. ATM Induces Cell Death with Autophagy in Response to H2O2 Specifically in Caenorhabditis elegans Nondividing Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211321
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211321
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر