Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells
المؤلفون المشاركون
Lenzi, Monia
Fiorentini, Diana
Prata, Cecilia
Facchini, Carlotta
Leoncini, Emanuela
Maraldi, Tullia
Angeloni, Cristina
Hrelia, Silvana
Zambonin, Laura
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Sulforaphane, a biologically active isothiocyanate compound extracted from cruciferous vegetables, has been shown to exert cytotoxic effects on many human cancer cells, including leukemia.
However, the exact molecular mechanisms behind the action of sulforaphane in hematological malignancies are still unclear.
Like other cancer cells, leukemia cells produce high level of reactive oxygen species; in particular, hydrogen peroxide derived from Nox family is involved in various redox signal transduction pathways, promoting cell proliferation and survival.
Recent evidence show that many tumour cell types express elevated level of aquaporin isoforms, and we previously demonstrated that aquaporin-8 acts as H2O2 transport facilitator across the plasma membrane of B1647 cells, a model of acute myeloid human leukemia.
Thus, the control of AQP8-mediated H2O2 transport could be a novel strategy to regulate cell signalling and survival.
To this purpose, we evaluated whether sulforaphane could somehow affect aquaporin-8-mediated H2O2 transport and/or Nox-mediated H2O2 production in B1647 cell line.
Results indicated that sulforaphane inhibited both aquaporin-8 and Nox2 expression, thus decreasing B1647 cells viability.
Moreover, the data obtained by coimmunoprecipitation technique demonstrated that these two proteins are linked to each other; thus, sulforaphane has an important role in modulating the downstream events triggered by the axis Nox2-aquaporin-8.
Cell treatment with sulforaphane also reduced the expression of peroxiredoxin-1, which is increased in almost all acute myeloid leukemia subtypes.
Interestingly, sulforaphane concentrations able to trigger these effects are achievable by dietary intake of cruciferous vegetables, confirming the importance of the beneficial effect of a diet rich in bioactive compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prata, Cecilia& Facchini, Carlotta& Leoncini, Emanuela& Lenzi, Monia& Maraldi, Tullia& Angeloni, Cristina…[et al.]. 2018. Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211386
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prata, Cecilia…[et al.]. Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211386
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prata, Cecilia& Facchini, Carlotta& Leoncini, Emanuela& Lenzi, Monia& Maraldi, Tullia& Angeloni, Cristina…[et al.]. Sulforaphane Modulates AQP8-Linked Redox Signalling in Leukemia Cells. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211386
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211386
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر