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Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOSNO-Regulated Oxidative Stress
المؤلفون المشاركون
Liao, Hai-Han
Yang, Zheng
Tang, Qi-Zhu
Duan, Ming-Xia
Wu, Qing-Qing
Liu, Chen
Xiao, Yang
Yuan, Yuan
Meng, Yan-yan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-25
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Whether aucubin could protect myocardial infarction- (MI-) induced cardiac remodeling is not clear.
In this study, in a mouse model, cardiac remodeling was induced by left anterior descending coronary artery ligation surgery.
Mice were intraperitoneally injected with aucubin (10 mg/kg) 3 days post-MI.
Two weeks post-MI, mice in the aucubin treatment group showed decreased mortality, decreased infarct size, and improved cardiac function.
Aucubin also decreased cardiac remodeling post-MI.
Consistently, aucubin protected cardiomyocytes against hypoxic injury in vitro.
Mechanistically, we found that aucubin inhibited the ASK1/JNK signaling.
These effects were abolished by the JNK activator.
Moreover, we found that the oxidative stress was attenuated in both in vivo aucubin-treated mice heart and in vitro-treated cardiomyocytes, which caused decreased thioredoxin (Trx) consumption, leading to ASK1 forming the inactive complex with Trx.
Aucubin increased nNOS-derived NO production in vivo and vitro.
The protective effects of aucubin were reversed by the NOS inhibitors L-NAME and L-VINO in vitro.
Furthermore, nNOS knockout mice also reversed the protective effects of aucubin on cardiac remodeling.
Taken together, aucubin protects against cardiac remodeling post-MI through activation of the nNOS/NO pathway, which subsequently attenuates the ROS production, increases Trx preservation, and leads to inhibition of the ASK1/JNK pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Zheng& Wu, Qing-Qing& Xiao, Yang& Duan, Ming-Xia& Liu, Chen& Yuan, Yuan…[et al.]. 2018. Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOSNO-Regulated Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211423
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Zheng…[et al.]. Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOSNO-Regulated Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1211423
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Zheng& Wu, Qing-Qing& Xiao, Yang& Duan, Ming-Xia& Liu, Chen& Yuan, Yuan…[et al.]. Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOSNO-Regulated Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211423
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211423
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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