Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOSNO-Regulated Oxidative Stress
المؤلفون المشاركون
Liao, Hai-Han
Yang, Zheng
Tang, Qi-Zhu
Duan, Ming-Xia
Wu, Qing-Qing
Liu, Chen
Xiao, Yang
Yuan, Yuan
Meng, Yan-yan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-25
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Whether aucubin could protect myocardial infarction- (MI-) induced cardiac remodeling is not clear.
In this study, in a mouse model, cardiac remodeling was induced by left anterior descending coronary artery ligation surgery.
Mice were intraperitoneally injected with aucubin (10 mg/kg) 3 days post-MI.
Two weeks post-MI, mice in the aucubin treatment group showed decreased mortality, decreased infarct size, and improved cardiac function.
Aucubin also decreased cardiac remodeling post-MI.
Consistently, aucubin protected cardiomyocytes against hypoxic injury in vitro.
Mechanistically, we found that aucubin inhibited the ASK1/JNK signaling.
These effects were abolished by the JNK activator.
Moreover, we found that the oxidative stress was attenuated in both in vivo aucubin-treated mice heart and in vitro-treated cardiomyocytes, which caused decreased thioredoxin (Trx) consumption, leading to ASK1 forming the inactive complex with Trx.
Aucubin increased nNOS-derived NO production in vivo and vitro.
The protective effects of aucubin were reversed by the NOS inhibitors L-NAME and L-VINO in vitro.
Furthermore, nNOS knockout mice also reversed the protective effects of aucubin on cardiac remodeling.
Taken together, aucubin protects against cardiac remodeling post-MI through activation of the nNOS/NO pathway, which subsequently attenuates the ROS production, increases Trx preservation, and leads to inhibition of the ASK1/JNK pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Zheng& Wu, Qing-Qing& Xiao, Yang& Duan, Ming-Xia& Liu, Chen& Yuan, Yuan…[et al.]. 2018. Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOSNO-Regulated Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211423
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Zheng…[et al.]. Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOSNO-Regulated Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1211423
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Zheng& Wu, Qing-Qing& Xiao, Yang& Duan, Ming-Xia& Liu, Chen& Yuan, Yuan…[et al.]. Aucubin Protects against Myocardial Infarction-Induced Cardiac Remodeling via nNOSNO-Regulated Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211423
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211423
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر