Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia
المؤلفون المشاركون
Liu, Xuan
Wang, Hairong
Gao, Chengjin
Wang, Yang
Pan, Shuming
Jiang, Shao-wei
Niu, Lei
Ge, Xiao-li
Zhang, Jin-cheng
Fei, Ai-hua
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Postcardiac arrest syndrome yields poor neurological outcomes, but the mechanisms underlying this condition remain poorly understood.
Autophagy plays an important role in neuronal apoptosis induced by ischemia.
However, whether autophagy is involved in neuron apoptosis induced by cardiac arrest has been less studied.
This study found that TRPML1 participates in cerebral ischemic reperfusion injury.
Primary neurons were isolated and treated with mucolipin synthetic agonist 1 (ML-SA1), as well as infected with the recombinant lentivirus TRPML1 overexpression vector in vitro.
ML-SA1 was delivered intracerebroventricularly in transient global ischemia model.
Protein expression levels were determined by western blot.
Neurological deficit score and the infarct volume were analyzed for the detection of neuronal damage.
We found that TRPML1 was significantly downregulated in vivo and in vitro ischemic reperfusion model.
We also observed that TRPML1 overexpression or treatment with the ML-SA1 attenuated neuronal death in primary neurons and ameliorated neurological dysfunction in vivo.
Our findings suggested that autophagy and apoptosis were activated after transient global ischemia.
Administration of ML-SA1 before transient global ischemia ameliorated neurological dysfunction possibly through the promotion of autophagy and the inhibition of apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yang& Jiang, Shao-wei& Liu, Xuan& Niu, Lei& Ge, Xiao-li& Zhang, Jin-cheng…[et al.]. 2018. Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211459
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yang…[et al.]. Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211459
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yang& Jiang, Shao-wei& Liu, Xuan& Niu, Lei& Ge, Xiao-li& Zhang, Jin-cheng…[et al.]. Degradation of TRPML1 in Neurons Reduces Neuron Survival in Transient Global Cerebral Ischemia. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211459
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211459
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر