Non-Provitamin A and Provitamin A Carotenoids as Immunomodulators: Recommended Dietary Allowance, Therapeutic Index, or Personalized Nutrition?
المؤلفون المشاركون
Peluso, Ilaria
Palmery, Maura
Valencia, Débora Villaño
Chen, Chung-Yen Oliver
Toti, Elisabetta
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-09
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Vegetables and fruits contain non-provitamin A (lycopene, lutein, and zeaxanthin) and provitamin A (β-carotene, β-cryptoxanthin, and α-carotene) carotenoids.
Within these compounds, β-carotene has been extensively studied for its health benefits, but its supplementation at doses higher than recommended intakes induces adverse effects.
β-Carotene is converted to retinoic acid (RA), a well-known immunomodulatory molecule.
Human interventions suggest that β-carotene and lycopene at pharmacological doses affect immune functions after a depletion period of low carotenoid diet.
However, these effects appear unrelated to carotenoids and retinol levels in plasma.
Local production of RA in the gut-associated lymphoid tissue, as well as the dependency of RA-induced effects on local inflammation, suggests that personalized nutrition/supplementation should be considered in the future.
On the other hand, the differential effect of RA and lycopene on transforming growth factor-beta suggests that lycopene supplementation could improve immune functions without increasing risk for cancers.
However, such preclinical evidence must be confirmed in human interventions before any recommendations can be made.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Toti, Elisabetta& Chen, Chung-Yen Oliver& Palmery, Maura& Valencia, Débora Villaño& Peluso, Ilaria. 2018. Non-Provitamin A and Provitamin A Carotenoids as Immunomodulators: Recommended Dietary Allowance, Therapeutic Index, or Personalized Nutrition?. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1211461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Toti, Elisabetta…[et al.]. Non-Provitamin A and Provitamin A Carotenoids as Immunomodulators: Recommended Dietary Allowance, Therapeutic Index, or Personalized Nutrition?. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1211461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Toti, Elisabetta& Chen, Chung-Yen Oliver& Palmery, Maura& Valencia, Débora Villaño& Peluso, Ilaria. Non-Provitamin A and Provitamin A Carotenoids as Immunomodulators: Recommended Dietary Allowance, Therapeutic Index, or Personalized Nutrition?. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1211461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر