Intravenous Anesthetic Protects Hepatocyte from Reactive Oxygen Species-Induced Cellular Apoptosis during Liver Transplantation In Vivo
المؤلفون المشاركون
Yao, Weifeng
Ge, Mian
Zhang, Yihan
Wu, Shan
Han, Xue
Chen, Chaojin
Guan, Jianqiang
Chen, Jiaxin
Huang, Pinjie
Luo, Gangjian
Hei, Ziqing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Liver transplantation leads to liver ischemia/reperfusion (I/R) injury, resulting in early graft dysfunction and failure.
Exacerbations of oxidative stress and inflammatory response are key processes in the development of liver I/R injury.
Intravenous anesthetic propofol potent effects on free radical scavenging and protects livers against I/R injury.
However, the role and mechanism of propofol-mediated hepatic protection in liver transplantation is poorly understood.
The aim of this study was to evaluate the role of propofol postconditioning in the liver I/R injury after liver transplantation.
Methods.
Forty-eight rats were randomly divided into six groups: rats receiving either sham operation or orthotopic autologous liver transplantation (OALT) in the absence or presence of propofol (high dose and low dose) postconditioning or intralipid control or VAS2870 (Nox2 special inhibitor).
Eight hours after OALT or sham operation, parameters of organ injury, oxidative stress, inflammation, and NADPH-associated proteins were assessed.
Results.
After OALT, severe liver pathological injury was observed that was associated with increases of serum AST and ALT, which were attenuated by propofol postconditioning.
In addition, especially high dose of propofol postconditioning reduced TNF-α, IL-1β, IL-6, TLR4, and NF-κB inflammatory pathway, accompanied with decrease of neutrophil elastase activity, MPO activity, 8-isoprotane, p47phox and gp91phox protein expressions, and increase of SOD activity.
Inhibition of Nox2 by VAS2870 conferred similar protective effects in liver transplantation.
Conclusion.
Liver transplantation leads to severe inflammation and oxidative stress with NADPH oxidase activation.
Propofol postconditioning reduces liver I/R injury after liver transplantation partly via inhibiting NADPH oxidase Nox2 and the subsequent inflammation and oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Weifeng& Han, Xue& Zhang, Yihan& Guan, Jianqiang& Ge, Mian& Chen, Chaojin…[et al.]. 2018. Intravenous Anesthetic Protects Hepatocyte from Reactive Oxygen Species-Induced Cellular Apoptosis during Liver Transplantation In Vivo. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211482
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Weifeng…[et al.]. Intravenous Anesthetic Protects Hepatocyte from Reactive Oxygen Species-Induced Cellular Apoptosis during Liver Transplantation In Vivo. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211482
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Weifeng& Han, Xue& Zhang, Yihan& Guan, Jianqiang& Ge, Mian& Chen, Chaojin…[et al.]. Intravenous Anesthetic Protects Hepatocyte from Reactive Oxygen Species-Induced Cellular Apoptosis during Liver Transplantation In Vivo. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211482
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211482
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر