Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine
المؤلفون المشاركون
O’Leary, Andrew J.
Drummond, Sarah E.
Edge, Deirdre
O’Halloran, Ken D.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-19
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Oxygen deficit (hypoxia) is a major feature of cardiorespiratory diseases characterized by diaphragm dysfunction, yet the putative role of hypoxic stress as a driver of diaphragm dysfunction is understudied.
We explored the cellular and functional consequences of sustained hypoxic stress in a mouse model.
Adult male mice were exposed to 8 hours of normoxia, or hypoxia (FiO2 = 0.10) with or without antioxidant pretreatment (N-acetyl cysteine, 200 mg/kg i.p.).
Ventilation and metabolism were measured.
Diaphragm muscle contractile function, myofibre size and distribution, gene expression, protein signalling cascades, and oxidative stress (TBARS) were determined.
Hypoxia caused pronounced diaphragm muscle weakness, unrelated to increased respiratory muscle work.
Hypoxia increased diaphragm HIF-1α protein content and activated MAPK, mTOR, Akt, and FoxO3a signalling pathways, largely favouring protein synthesis.
Hypoxia increased diaphragm lipid peroxidation, indicative of oxidative stress.
FoxO3 and MuRF-1 gene expression were increased.
Diaphragm 20S proteasome activity and muscle fibre size and distribution were unaffected by acute hypoxia.
Pretreatment with N-acetyl cysteine substantially enhanced cell survival signalling, prevented hypoxia-induced diaphragm oxidative stress, and prevented hypoxia-induced diaphragm dysfunction.
Hypoxia is a potent driver of diaphragm weakness, causing myofibre dysfunction without attendant atrophy.
N-acetyl cysteine protects the hypoxic diaphragm and may have application as a potential adjunctive therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
O’Leary, Andrew J.& Drummond, Sarah E.& Edge, Deirdre& O’Halloran, Ken D.. 2018. Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1211489
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
O’Leary, Andrew J.…[et al.]. Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-19.
https://search.emarefa.net/detail/BIM-1211489
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
O’Leary, Andrew J.& Drummond, Sarah E.& Edge, Deirdre& O’Halloran, Ken D.. Diaphragm Muscle Weakness Following Acute Sustained Hypoxic Stress in the Mouse Is Prevented by Pretreatment with N-Acetyl Cysteine. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-19.
https://search.emarefa.net/detail/BIM-1211489
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211489
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر