Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice
المؤلفون المشاركون
Fernandes, Elizabeth S.
Brain, Susan D.
Grisotto, Marcos A. G.
Monteiro-Neto, Valério
Pereira, Domingos Magno Santos
Sousa, Nágila Caroline Fialho
Calixto, João Batista
Mendes, Saulo J. F.
Alawi, Khadija
Thakore, Pratish
Aubdool, Aisah
da Silva, João F. R.
Castro, José A.
P. Pereira, Ione C.
Costa, Soraia K. P.
da Costa, Robson
Nascimento da Silva, Luís Cláudio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Thioredoxin plays an essential role in bacterial antioxidant machinery and virulence; however, its regulatory actions in the host are less well understood.
Reduced human Trx activates transient receptor potential canonical 5 (TRPC5) in inflammation, but there is no evidence of whether these receptors mediate bacterial thioredoxin effects in the host.
Importantly, TRPC5 can form functional complexes with other subunits such as TRPC4.
Herein, E.
coli-derived thioredoxin induced mortality in lipopolysaccharide- (LPS-) injected mice, accompanied by reduction of leukocyte accumulation, regulation of cytokine release into the peritoneum, and impairment of peritoneal macrophage-mediated phagocytosis.
Dual TRPC4/TRPC5 blockade by ML204 increased mortality and hypothermia in thioredoxin-treated LPS mice but preserved macrophage’s ability to phagocytose.
TRPC5 deletion did not alter body temperature but promoted additional accumulation of peritoneal leukocytes and inflammatory mediator release in thioredoxin-administered LPS mice.
Thioredoxin diminished macrophage-mediated phagocytosis in wild-type but not TRPC5 knockout animals.
TRPC5 ablation did not affect LPS-induced responses.
However, ML204 caused mortality associated with exacerbated hypothermia and decreased peritoneal leukocyte numbers and cytokines in LPS-injected mice.
These results suggest that bacterial thioredoxin effects under LPS stimuli are mediated by TRPC4 and TRPC5, shedding light on the additional mechanisms of bacterial virulence and on the pathophysiological roles of these receptors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pereira, Domingos Magno Santos& Mendes, Saulo J. F.& Alawi, Khadija& Thakore, Pratish& Aubdool, Aisah& Sousa, Nágila Caroline Fialho…[et al.]. 2018. Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pereira, Domingos Magno Santos…[et al.]. Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1211511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pereira, Domingos Magno Santos& Mendes, Saulo J. F.& Alawi, Khadija& Thakore, Pratish& Aubdool, Aisah& Sousa, Nágila Caroline Fialho…[et al.]. Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1211511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر