Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress
المؤلفون المشاركون
Biagioni, Francesca
Fornai, Francesco
Gambardella, Stefano
Limanaqi, Fiona
Busceti, Carla L.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-28، 28ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-22
دولة النشر
مصر
عدد الصفحات
28
التخصصات الرئيسية
الملخص EN
Methamphetamine is a widely abused drug, which possesses neurotoxic activity and powerful addictive effects.
Understanding methamphetamine toxicity is key beyond the field of drug abuse since it allows getting an insight into the molecular mechanisms which operate in a variety of neuropsychiatric disorders.
In fact, key alterations produced by methamphetamine involve dopamine neurotransmission in a way, which is reminiscent of spontaneous neurodegeneration and psychiatric schizophrenia.
Thus, understanding the molecular mechanisms operated by methamphetamine represents a wide window to understand both the addicted brain and a variety of neuropsychiatric disorders.
This overlapping, which is already present when looking at the molecular and cellular events promoted immediately after methamphetamine intake, becomes impressive when plastic changes induced in the brain of methamphetamine-addicted patients are considered.
Thus, the present manuscript is an attempt to encompass all the molecular events starting at the presynaptic dopamine terminals to reach the nucleus of postsynaptic neurons to explain how specific neurotransmitters and signaling cascades produce persistent genetic modifications, which shift neuronal phenotype and induce behavioral alterations.
A special emphasis is posed on disclosing those early and delayed molecular events, which translate an altered neurotransmitter function into epigenetic events, which are derived from the translation of postsynaptic noncanonical signaling into altered gene regulation.
All epigenetic effects are considered in light of their persistent changes induced in the postsynaptic neurons including sensitization and desensitization, priming, and shift of neuronal phenotype.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Limanaqi, Fiona& Gambardella, Stefano& Biagioni, Francesca& Busceti, Carla L.& Fornai, Francesco. 2018. Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-28.
https://search.emarefa.net/detail/BIM-1211549
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Limanaqi, Fiona…[et al.]. Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-28.
https://search.emarefa.net/detail/BIM-1211549
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Limanaqi, Fiona& Gambardella, Stefano& Biagioni, Francesca& Busceti, Carla L.& Fornai, Francesco. Epigenetic Effects Induced by Methamphetamine and Methamphetamine-Dependent Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-28.
https://search.emarefa.net/detail/BIM-1211549
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211549
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر