Anti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis
المؤلفون المشاركون
Souza, Gustavo Henrique Bianco de
Costa, Daniela Caldeira
Talvani, André
Bezerra, Frank Silva
de Souza, Débora Maria Soares
Brandão, Geraldo Célio
Rabelo, Ana Carolina Silveira
de Pádua Lúcio, Karine
Araújo, Carolina Morais
da Silva, Regislainy Gomes
Cruz Calsavara, Allan Jefferson
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Sepsis is a complex disease and is the cause of many deaths worldwide.
Sepsis pathogenesis involves a dysregulated inflammatory response with consequent production of inflammatory mediators and reactive species.
The production and excessive release of these substances into the systemic circulation trigger various cellular and metabolic alterations that are observed during the disease evolution.
Thus, more studies have been carried out to investigate the therapeutic potential of plants such as Morus nigra L., popularly known as black mulberry.
Studies have shown that plants belonging to the Morus genus are rich in secondary metabolites such as flavonoids which are associated with important biological activities as antioxidant and anti-inflammatory actions.
Based on this context, the objective of our study was to evaluate the anti-inflammatory and antioxidant properties of Morus nigra L.
in a sepsis model induced by LPS.
Male C57BL/6 mice were distributed in four groups: control, sepsis, sepsis treated with leaf extract of mulberry, and sepsis treated with mulberry pulp.
The animals were treated with 100 μL of their respective treatments for twenty-one days.
Sepsis was induced at the 21st day with lipopolysaccharide (LPS) by intraperitoneal injection.
The animals were euthanized 24 hours after receiving the LPS injection.
The data obtained were analyzed in GraphPad Prism 6.0 software.
Our results showed that treatment with either extract significantly decreased the number of leukocytes in the bronchoalveolar lavage fluid and serum levels of TNF in septic animals.
Regarding the redox status, the treatments significantly decreased the antioxidant activity of the enzyme glutathione peroxidase.
Regarding metalloproteinase type 2, it was observed that the treatment with black mulberry pulp was able to significantly reduce the activity of this enzyme concerning the sepsis group.
Finally, these results together promoted an increase in the animal’s survival that received the black mulberry leaf or pulp extract.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Pádua Lúcio, Karine& Rabelo, Ana Carolina Silveira& Araújo, Carolina Morais& Brandão, Geraldo Célio& Souza, Gustavo Henrique Bianco de& da Silva, Regislainy Gomes…[et al.]. 2018. Anti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211559
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Pádua Lúcio, Karine…[et al.]. Anti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211559
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Pádua Lúcio, Karine& Rabelo, Ana Carolina Silveira& Araújo, Carolina Morais& Brandão, Geraldo Célio& Souza, Gustavo Henrique Bianco de& da Silva, Regislainy Gomes…[et al.]. Anti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211559
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211559
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر