Rutin Isolated from Chrozophora tinctoria Enhances Bone Cell Proliferation and Ossification Markers
المؤلفون المشاركون
Eid, Basma G.
Al-Abd, Ahmed M.
Abdel-Naim, Ashraf B.
Alghamdi, Abdullah A.
Algandaby, Mardi M.
Abdallah, Hossam M.
El-Halawany, Ali M.
al-Abbasi, Fahad A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-13
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Osteoporosis is a chronic disease in which the skeleton loses a weighty proportion of its mineralized mass and mechanical pliability.
Currently available antiosteoporotic agents suffer adverse effects that include elevated risk of thrombosis and cancer.
Phytochemicals may constitute a safer and effective option.
In the current work, six flavonoids were obtained from Chrozophora tinctoria and identified as amentoflavone (1), apigenin-7-O-β-d-glucopyranoside (2), apigenin-7-O-6′′-E-p-coumaroyl-β-d-glucopyranoside (3), acacetin-7-O-β-d-[α-l-rhamnosyl(1→6)]3′′-E-p-coumaroyl glucopyranoside (4), apigenin-7-O-(6′′-Z-p-coumaroyl)-β-d-glucopyranoside (5), and rutin (6).
An extensive review of the literature as well as NMR and mass spectral techniques was employed in order to elucidate the compound structures.
Proliferation was enhanced in MCF7, MG-63, and SAOS-2 cells after exposure to subcytotoxic levels of the tested flavonoids.
Rutin was chosen for subsequent studies in SAOS-2 cells.
Rutin was not found to cause any alteration in the index of proliferation of these cells, when examining the cell cycle distribution by DNA flowcytometric analysis.
Rutin was, however, found to increase osteocyte and osteoblast-related gene expression and lower the expression of RUNX suppressor and osteoclast genes.
When examining the influence of rutin on vitamin D levels and the activity of alkaline phosphatase enzyme, it was found to enhance both, while decreasing acid phosphatase which is a marker of osteoporosis.
Thus, rutin enhances proliferation and ossification markers in bone cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdel-Naim, Ashraf B.& Alghamdi, Abdullah A.& Algandaby, Mardi M.& al-Abbasi, Fahad A.& Al-Abd, Ahmed M.& Eid, Basma G.…[et al.]. 2018. Rutin Isolated from Chrozophora tinctoria Enhances Bone Cell Proliferation and Ossification Markers. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211568
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdel-Naim, Ashraf B.…[et al.]. Rutin Isolated from Chrozophora tinctoria Enhances Bone Cell Proliferation and Ossification Markers. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1211568
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdel-Naim, Ashraf B.& Alghamdi, Abdullah A.& Algandaby, Mardi M.& al-Abbasi, Fahad A.& Al-Abd, Ahmed M.& Eid, Basma G.…[et al.]. Rutin Isolated from Chrozophora tinctoria Enhances Bone Cell Proliferation and Ossification Markers. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1211568
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211568
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر