Protective Effects of a Polyphenol-Rich Extract from Syzygium cumini (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats
المؤلفون المشاركون
Ribeiro, Maria Nilce Sousa
Trostchansky, Andrés
Gaspar, Renato Simões
Paes, Antonio Marcus de Andrade
Chagas, Vinicyus Teles
de Sousa Coelho, Rafaella Moraes Rego
da Silva, Samira Abdalla
Mastrogiovanni, Mauricio
de Jesus Mendonça, Cáritas
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-26
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Syzygium cumini (L.) Skeels has been reported to exert anti-inflammatory and cardiometabolic activities due to its high content of polyphenols.
We characterized the chemical composition and assessed the antidiabetic effects of a novel polyphenol-rich extract (PESc) obtained from S.
cumini leaf.
Rats were injected with alloxan (150 mg/kg, ip, ALX group) and followed up for 7 days.
Some were orally treated with PESc (50 mg/kg/day) for 7 days before and after diabetes induction (ALX-PP) or only for 7 days after alloxan injection (ALX-P).
ALX-P and ALX-PP decreased fasting glycemia in 37 and 43%, respectively, as compared to ALX.
Triglycerides and total cholesterol serum levels were also significantly reduced in comparison to ALX.
PESc presented high polyphenol concentration (71.78 ± 8.57 GAE/100 g), with flavonoid content of 8.21 ± 0.42 QE/100 g.
Upon HPLC-MS/MS and MS/MS studies, five main polyphenols—gallic acid, quercetin, myricetin, and its derivatives—were identified.
Myricetin was predominant (192.70 ± 16.50 μg/mg PESc), followed by measurable amounts of gallic acid (11.15 ± 0.90 μg/mg PESc) and quercetin (4.72 ± 0.06 μg/mg PESc).
Kinetic assessment of total antioxidant capacity revealed PESc high potency, since maximum response was reached within 5 min reaction time in a concentration-dependent manner.
Specific antioxidant activity of PESc was assessed against both DPPH• and ABTS•+, showing strong activity (IC50: 3.88 ± 1.09 and 5.98 ± 1.19 μg/mL, resp.).
PESc also inhibited lipoxygenase activity (IC50: 27.63 ± 8.47), confirming its antioxidant activity also on biologically relevant radicals.
Finally, PESc induced insulin secretion by directly stimulating INS-1E β cells in the absence of any cytotoxic effect.
Overall, our results support that PESc is a potent antioxidant phytocomplex with potential pharmacological use as a preventive antidiabetic natural product.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chagas, Vinicyus Teles& de Sousa Coelho, Rafaella Moraes Rego& Gaspar, Renato Simões& da Silva, Samira Abdalla& Mastrogiovanni, Mauricio& de Jesus Mendonça, Cáritas…[et al.]. 2018. Protective Effects of a Polyphenol-Rich Extract from Syzygium cumini (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211620
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chagas, Vinicyus Teles…[et al.]. Protective Effects of a Polyphenol-Rich Extract from Syzygium cumini (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211620
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chagas, Vinicyus Teles& de Sousa Coelho, Rafaella Moraes Rego& Gaspar, Renato Simões& da Silva, Samira Abdalla& Mastrogiovanni, Mauricio& de Jesus Mendonça, Cáritas…[et al.]. Protective Effects of a Polyphenol-Rich Extract from Syzygium cumini (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211620
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211620
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر