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The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert-Butyl Hydroperoxide-Induced Neuron Oxidative Damage
المؤلفون المشاركون
Zhu, Lihong
Lu, Da-xiang
Huang, Cuiqin
Gan, Danhui
Fan, Chongzhu
Wen, Caiyan
Li, An
Li, Qin
Zhao, Jiayi
Wang, Zhen
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-22
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Neural stem cells (NSCs) hold great potential for the treatment of Alzheimer’s disease (AD) through both cellular replacement and their secretion of trophic factors.
Lycopene is a potent β-carotenoid antioxidant that has been shown to ameliorate oxidative damage in previous studies.
However, it is unclear if lycopene can interact with NSCs to induce the secretion of growth factors, and whether pretreatment with lycopene will allow NSCs to secrete enough trophic factors to reduce oxidative damage to neurons.
We pretreated cultured NSCs with lycopene, then applied the lycopene-treated-NSC-conditioned media (Ly-NSC-CM) to primary neuronal cultures exposed to tert-butyl hydroperoxide (t-BHP) to induce oxidative damage.
We found that lycopene promoted the secretion of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) from NSCs.
In addition, Ly-NSC-CM attenuated oxidative stress and reduced t-BHP-induced cell apoptosis.
We found an antiapoptotic effect related to inhibited expression of Bax/Bcl-2, cytochrome C, and cleaved caspase-3.
Moreover, Ly-NSC-CM increased the levels of synaptic proteins, including synaptophysin (SYP) and postsynaptic density 95 (PSD-95), and activated the PI3K/Akt pathway in cultured neurons.
Collectively, these data indicate that Ly-NSC-CM could protect neurons from t-BHP-induced oxidative damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Cuiqin& Gan, Danhui& Fan, Chongzhu& Wen, Caiyan& Li, An& Li, Qin…[et al.]. 2018. The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert-Butyl Hydroperoxide-Induced Neuron Oxidative Damage. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211643
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Cuiqin…[et al.]. The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert-Butyl Hydroperoxide-Induced Neuron Oxidative Damage. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1211643
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Cuiqin& Gan, Danhui& Fan, Chongzhu& Wen, Caiyan& Li, An& Li, Qin…[et al.]. The Secretion from Neural Stem Cells Pretreated with Lycopene Protects against tert-Butyl Hydroperoxide-Induced Neuron Oxidative Damage. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1211643
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211643
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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