Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology
المؤلفون المشاركون
Vicente, João B.
Giuffrè, Alessandro
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-31، 31ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-27
دولة النشر
مصر
عدد الصفحات
31
التخصصات الرئيسية
الملخص EN
Hydrogen sulfide (H2S) has emerged as a relevant signaling molecule in physiology, taking its seat as a bona fide gasotransmitter akin to nitric oxide (NO) and carbon monoxide (CO).
After being merely regarded as a toxic poisonous molecule, it is now recognized that mammalian cells are equipped with sophisticated enzymatic systems for H2S production and breakdown.
The signaling role of H2S is mainly related to its ability to modify different protein targets, particularly by promoting persulfidation of protein cysteine residues and by interacting with metal centers, mostly hemes.
H2S has been shown to regulate a myriad of cellular processes with multiple physiological consequences.
As such, dysfunctional H2S metabolism is increasingly implicated in different pathologies, from cardiovascular and neurodegenerative diseases to cancer.
As a highly diffusible reactive species, the intra- and extracellular levels of H2S have to be kept under tight control and, accordingly, regulation of H2S metabolism occurs at different levels.
Interestingly, even though H2S, NO, and CO have similar modes of action and parallel regulatory targets or precisely because of that, there is increasing evidence of a crosstalk between the three gasotransmitters.
Herein are reviewed the biochemistry, metabolism, and signaling function of hydrogen sulfide, as well as its interplay with the other gasotransmitters, NO and CO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giuffrè, Alessandro& Vicente, João B.. 2018. Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-31.
https://search.emarefa.net/detail/BIM-1211780
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giuffrè, Alessandro& Vicente, João B.. Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-31.
https://search.emarefa.net/detail/BIM-1211780
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giuffrè, Alessandro& Vicente, João B.. Hydrogen Sulfide Biochemistry and Interplay with Other Gaseous Mediators in Mammalian Physiology. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-31.
https://search.emarefa.net/detail/BIM-1211780
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211780
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر