Endothelium as a Potential Target for Treatment of Abdominal Aortic Aneurysm
المؤلفون المشاركون
Xiong, Xiaoxing
Gao, Ling
Sun, Jingyuan
Deng, Hongping
Zhou, Zhen
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-03
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Abdominal aortic aneurysm (AAA) was previously ascribed to weaken defective medial arterial/adventitial layers, for example, smooth muscle/fibroblast cells.
Therefore, besides surgical repair, medications targeting the medial layer to strengthen the aortic wall are the most feasible treatment strategy for AAA.
However, so far, it is unclear whether such drugs have any beneficial effect on AAA prognosis, rate of aneurysm growth, rupture, or survival.
Notably, clinical studies have shown that AAA is highly associated with endothelial dysfunction in the aged population.
Additionally, animal models of endothelial dysfunction and endothelial nitric oxide synthase (eNOS) uncoupling had a very high rate of AAA formation, indicating there is crucial involvement of the endothelium and a possible pharmacological solution targeting the endothelium in AAA treatment.
Endothelial cells have been found to trigger vascular wall remodeling by releasing proteases, or recruiting macrophages along with other neutrophils, into the medial layer.
Moreover, inflammation and oxidative stress of the arterial wall were induced by endothelial dysfunction.
Interestingly, there is a paradoxical differential correlation between diabetes and aneurysm formation in retinal capillaries and the aorta.
Deciphering the significance of such a difference may explain current unsuccessful AAA medications and offer a solution to this treatment challenge.
It is now believed that AAA and atherosclerosis are two separate but related diseases, based on their different clinical patterns which have further complicated the puzzle.
Therefore, a thorough investigation of the interaction between endothelium and medial/adventitial layer may provide us a better understanding and new perspective on AAA formation, especially after taking into account the importance of endothelium in the development of AAA.
Moreover, a novel medication strategy replacing the currently used, but suboptimal treatments for AAA, could be informed with this analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Jingyuan& Deng, Hongping& Zhou, Zhen& Xiong, Xiaoxing& Gao, Ling. 2018. Endothelium as a Potential Target for Treatment of Abdominal Aortic Aneurysm. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211785
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Jingyuan…[et al.]. Endothelium as a Potential Target for Treatment of Abdominal Aortic Aneurysm. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211785
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Jingyuan& Deng, Hongping& Zhou, Zhen& Xiong, Xiaoxing& Gao, Ling. Endothelium as a Potential Target for Treatment of Abdominal Aortic Aneurysm. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211785
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211785
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر