Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity
المؤلفون المشاركون
Oelze, Matthias
Daiber, Andreas
Vahl, Christian-Friedrich
Buschmann, Katja
Münzel, Thomas
Gramlich, Yves
Hink, Ulrich
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-17
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Obesity is one of the major cardiovascular risk factors and is associated with oxidative stress and myocardial dysfunction.
We hypothesized that obesity affects cardiac function and morbidity by causing alterations in enzymatic redox patterns.
Methods.
Sixty-one patients undergoing coronary artery bypass grafting (CABG) were included in the study.
Excessive right atrial myocardial tissue emerging from the operative connection to the extracorporeal circulation was harvested.
Patients were assigned to control (n=19, body mass index (BMI): <25 kg/m2), overweight (n=25, 25 kg/m2 < BMI < 30 kg/m2), or obese (n=17, BMI: >30 kg/m2) groups.
Oxidative enzyme systems were studied directly in the cardiac muscles of patients undergoing CABG who were grouped according to BMI.
Molecular biological methods and high-performance liquid chromatography were used to detect the expression and activity of oxidative enzymes and the formation of reactive oxygen species (ROS).
Results.
We found increased levels of ROS and increased expression of ROS-producing enzymes (i.e., p47phox, xanthine oxidase) and decreased antioxidant defense mechanisms (mitochondrial aldehyde dehydrogenase, heme oxygenase-1, and eNOS) in line with elevated inflammatory markers (vascular cell adhesion molecule-1) in the right atrial myocardial tissue and by trend also in serum (sVCAM-1 and CCL5/RANTES).
Conclusion.
Increasing BMI in patients undergoing CABG is related to altered myocardial redox patterns, which indicates increased oxidative stress with inadequate antioxidant compensation.
These changes suggest that the myocardium of obese patients suffering from coronary artery disease is more susceptible to cardiomyopathy and possible damage by ischemia and reperfusion, for example, during cardiac surgery.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gramlich, Yves& Daiber, Andreas& Buschmann, Katja& Oelze, Matthias& Vahl, Christian-Friedrich& Münzel, Thomas…[et al.]. 2018. Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gramlich, Yves…[et al.]. Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1211837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gramlich, Yves& Daiber, Andreas& Buschmann, Katja& Oelze, Matthias& Vahl, Christian-Friedrich& Münzel, Thomas…[et al.]. Oxidative Stress in Cardiac Tissue of Patients Undergoing Coronary Artery Bypass Graft Surgery: The Effects of Overweight and Obesity. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1211837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر