Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans
المؤلفون المشاركون
Owiredu, Eddie-Williams
Annani-Akollor, Max Efui
Addai-Mensah, Otchere
Gyamfi, Daniel
Duneeh, Richard Vikpebah
Danquah, Kwabena O.
Boateng, Lillian
Amponsah, Francis A.
Afriyie, Edward Y.
Asare, Renate
Ofosu, David Ntiamoah
Boateng, Richard
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
Introduction.
The pathophysiology of malaria-related anaemia is not fully understood although increased destruction of parasitized and nonparasitized erythrocytes, as well as inadequate erythropoiesis, has been proposed.
Circulating antierythropoietin (anti-EPO) antibodies have also been implicated in malaria and malaria-related anaemia in mice.
However, studies on this association have not been investigated in humans.
This study therefore determined the prevalence of anti-EPO antibody production and assessed its association with malaria and malaria-related anaemia in humans.
Methods.
A total of 86 children aged 1-10 years (57 children with malaria serving as the case group and 29 healthy children serving as control), all residents of Duayaw Nkwanta, Ghana, were recruited for this case-control study.
Venous blood was collected for thick and thin films for malaria microscopy, full blood count by automated haematology analyzer, and antierythropoietin antibody and erythropoietin estimation by sandwich ELISA method.
Results.
Out of the 86 participants recruited, only 3 (3.5%) were positive for anti-EPO antibody; 2.3% of the case group; and 1.2% of the control group.
There was no association between the cases and the controls in the production of anti-EPO antibodies.
Erythropoietin concentration was significantly higher in malaria-related anaemic subjects (p=0.032).
Conclusion.
Antierythropoietin antibodies are not associated with malaria infection and malaria-related anaemia in humans.
Erythropoietin concentration is associated with malaria-related anaemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Addai-Mensah, Otchere& Gyamfi, Daniel& Amponsah, Francis A.& Annani-Akollor, Max Efui& Danquah, Kwabena O.& Boateng, Lillian…[et al.]. 2019. Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans. The Scientific World Journal،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1211848
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Addai-Mensah, Otchere…[et al.]. Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans. The Scientific World Journal No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1211848
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Addai-Mensah, Otchere& Gyamfi, Daniel& Amponsah, Francis A.& Annani-Akollor, Max Efui& Danquah, Kwabena O.& Boateng, Lillian…[et al.]. Antierythropoietin Antibody Production Is Not Associated with Malaria and Malaria-Related Anaemia in Humans. The Scientific World Journal. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1211848
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211848
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر