![](/images/graphics-bg.png)
Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats
المؤلفون المشاركون
Varga, Csaba
Török, Szilvia
Al-awar, Amin
Juhász, Béla
Börzsei, Denise
Karácsonyi, Zoltán
Takács, István
Kupai, Krisztina
Berkó, Anikó
Pósa, Anikó
Szabó, Renáta
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Myocardial extracellular matrix (ECM) is essential for proper cardiac function and structural integrity; thus, the disruption of ECM homeostasis is associated with several pathological processes.
Female Wistar rats underwent surgical ovariectomy (OVX) or sham operation (SO) and were then divided into eight subgroups based on the type of diet (standard chow or high-triglyceride diet/HT) and exercise (with or without running).
After 12 weeks, cardiac MMP-2 activity, tissue inhibitor of metalloproteinase-2, content of collagen type I, the level of nitrotyrosine (3-NT) and glutathione (GSH), and the ratio of infarct size were determined.
Our results show that OVX and HT diet caused an excessive accumulation of collagen; however, this increase was not observed in the trained animals.
Twelve weeks of exercise promoted elevation in the levels of 3-NT and GSH and similarly an increase in MMP-2 activity of both SO and OVX animals.
The high infarct-size ratio caused by OVX and HT diet was mitigated by physical exercise.
Our findings demonstrate that ovarian estrogen loss and HT diet caused collagen accumulation and increased ratio of the infarct size.
However, exercise-induced cardiac remodeling serves as a compensatory mechanism by enhancing MMP-2 activity and reducing fibrosis, thus minimizing the ischemia/reperfusion injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Szabó, Renáta& Karácsonyi, Zoltán& Börzsei, Denise& Juhász, Béla& Al-awar, Amin& Török, Szilvia…[et al.]. 2018. Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211849
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Szabó, Renáta…[et al.]. Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1211849
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Szabó, Renáta& Karácsonyi, Zoltán& Börzsei, Denise& Juhász, Béla& Al-awar, Amin& Török, Szilvia…[et al.]. Role of Exercise-Induced Cardiac Remodeling in Ovariectomized Female Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1211849
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211849
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)