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Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor
المؤلفون المشاركون
Horliana, Anna Carolina Ratto Tempestini
Lino-dos-Santos-Franco, Adriana
Vieira, Rodolfo P.
Oliveira-Junior, Manoel Carneiro
Rigonato-Oliveira, Nicole Cristine
Brito, Auriléia Aparecida de
Vitoretti, Luana Beatriz
de Cunha Moraes, Gabriel
Alves, Cintia Estefano
Aimbire, Flávio
Ligeiro de Oliveira, Ana Paula
dos Santos Dias, Alana
Matos, Yves Silva Teles
Oliveira, Luis Vicente Franco
da Palma, Renata Kelly
Candeo, Larissa Carbonera
Gimenes Júnior, João Antonio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible airflow limitation, airway inflammation and remodeling, and enlargement of alveolar spaces.
COPD is in the top five leading causes of deaths worldwide and presents a high economic cost.
However, there are some preventive measures to lower the risk of developing COPD.
Low-level laser therapy (LLLT) is a new effective therapy, with very low cost and no side effects.
So, our objective was to investigate if LLLT reduces pulmonary alterations in an experimental model of COPD.
C57BL/6 mice were submitted to cigarette smoke for 75 days (2x/day).
After 60 days to smoke exposure, the treated group was submitted to LLLT (diode laser, 660 nm, 30 mW, and 3 J/cm2) for 15 days and euthanized for morphologic and functional analysis of the lungs.
Our results showed that LLLT significantly reduced the number of inflammatory cells and the proinflammatory cytokine secretion such as IL-1β, IL-6, and TNF-α in bronchoalveolar lavage fluid (BALF).
We also observed that LLLT decreased collagen deposition as well as the expression of purinergic P2X7 receptor.
On the other hand, LLLT increased the IL-10 release.
Thus, LLLT can be pointed as a promising therapeutic approach for lung inflammatory diseases as COPD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Cunha Moraes, Gabriel& Vitoretti, Luana Beatriz& Brito, Auriléia Aparecida de& Alves, Cintia Estefano& Rigonato-Oliveira, Nicole Cristine& dos Santos Dias, Alana…[et al.]. 2018. Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Cunha Moraes, Gabriel…[et al.]. Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Cunha Moraes, Gabriel& Vitoretti, Luana Beatriz& Brito, Auriléia Aparecida de& Alves, Cintia Estefano& Rigonato-Oliveira, Nicole Cristine& dos Santos Dias, Alana…[et al.]. Low-Level Laser Therapy Reduces Lung Inflammation in an Experimental Model of Chronic Obstructive Pulmonary Disease Involving P2X7 Receptor. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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