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Effect of Metronidazole on the Oxidoreductive Processes in the Submandibular and Parotid Glands in Experimental Research
المؤلفون المشاركون
Dąbrowska, Zofia
Dąbrowska, Ewa
Onopiuk, Barbara
Onopiuk, Paweł
Pietruska, Małgorzata
Car, Halina
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Oxidative stress takes part in the pathomechanisms of many diseases, including oral disorders.
The imbalance between oxidative and antioxidative processes may lead to periodontitis, osteitis, or oral cancers.
Furthermore, many chemotherapeutics, e.g., metronidazole (MTZ), may also cause toxic reactions and affect oxidative reactions.
The research focused on MTZ influence on oxidative destruction in the parotid and submandibular gland tissue in animal experimental model.
Therefore, the concentrations of enzymatic and nonenzymatic markers of oxidative stress were measured in these two rat glands in the control and experimental MTZ-treated groups.
The material for analysis included parotid and submandibular glands of male Wistar rats, which were treated with metronidazole for 7 days by gastric tube in a dose of 100 mg/kg b.w.
On day 8, the material was obtained and frozen in temp.
−80°C.
Then, the following seven enzymatic and nonenzymatic parameters were measured: GPx, TOS, TAS, SOD, LPO, CAT, and GSH.
The data were analysed using Statistica 10.0.
Metronidazole treatment in the experimental model showed an increase in LPO, TOS, and TOS/TAS and a decrease in CAT, SOD, GPx, and TAS.
The conclusions of this research were made.
Metronidazole treatment in a dose of 100 mg/kg b.w.
caused imbalance between oxidative and antioxidative reactions in the rat parotid and submandibular glands.
An increase was observed in LPO, TOS, and TOS/TAS in both glands exposed to metronidazole.
Decreased activity of CAT, SOD, GPx, and TAS was noted, which indicates attenuation of the gland antioxidative protective barrier.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Onopiuk, Barbara& Onopiuk, Paweł& Dąbrowska, Zofia& Dąbrowska, Ewa& Pietruska, Małgorzata& Car, Halina. 2018. Effect of Metronidazole on the Oxidoreductive Processes in the Submandibular and Parotid Glands in Experimental Research. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Onopiuk, Barbara…[et al.]. Effect of Metronidazole on the Oxidoreductive Processes in the Submandibular and Parotid Glands in Experimental Research. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Onopiuk, Barbara& Onopiuk, Paweł& Dąbrowska, Zofia& Dąbrowska, Ewa& Pietruska, Małgorzata& Car, Halina. Effect of Metronidazole on the Oxidoreductive Processes in the Submandibular and Parotid Glands in Experimental Research. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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