Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress
المؤلفون المشاركون
Atli, Ozlem
Aydoğan-Kılıç, Gözde
Baysal, Merve
Kılıç, Volkan
Ardıç, Mina
Uçarcan, Şeyda
Ilgin, Sinem
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Depression and anxiety are recognized as public health problems.
Epidemiological studies have shown that depression and anxiety often occur during reproductive ages between 20 and 60 years of age in males.
Trazodone is one of the most frequently prescribed drugs in the treatment of depression and anxiety.
Drugs used in repeated doses also play a role in the etiology of infertility.
In our study, it was aimed to identify the possible toxic effects of trazodone on male rats and elucidate the underlying mechanisms.
Vehicle or trazodone (5, 10, and 20 mg/kg/day) was administered to rats for 28 consecutive days (n=8 per group).
At the end of that period, sperm concentration, motility, morphology, and DNA damage were determined and testicular morphology was assessed histopathologically in rats.
Additionally, we investigated hormonal status by determining serum testosterone, FSH, and LH levels and oxidative stress by determining glutathione and malondialdehyde levels in testicular tissue to elucidate mechanisms of possible reproductive toxicity.
According to our results, sperm concentration, sperm motility, and normal sperm morphology were decreased; sperm DNA damage was increased in trazodone-administered groups.
Degenerative findings on the testicular structure were observed after trazodone administration in rats.
Additionally, serum FSH, LH, and testosterone levels were elevated in the trazodone-administered groups.
Increased MDA levels were the signs of enhanced oxidative stress after trazodone administration in testis tissues.
Thus, we concluded that trazodone induced reproductive toxicity in male rats; this reproductive toxicity was accompanied by oxidative stress and hormonal changes, which are considered as important causes of reproductive disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ilgin, Sinem& Aydoğan-Kılıç, Gözde& Baysal, Merve& Kılıç, Volkan& Ardıç, Mina& Uçarcan, Şeyda…[et al.]. 2018. Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211963
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ilgin, Sinem…[et al.]. Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1211963
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ilgin, Sinem& Aydoğan-Kılıç, Gözde& Baysal, Merve& Kılıç, Volkan& Ardıç, Mina& Uçarcan, Şeyda…[et al.]. Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1211963
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211963
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر