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Impact of Ileal Transposition Surgical Intervention on Antioxidant Status Measured in Liver Tissue of Obese Zucker Rats (Crl:ZUC-Leprfa)
المؤلفون المشاركون
Romuk, Ewa
Skrzep-Poloczek, Bronisława
Stygar, Dominika
Chełmecka, Elżbieta
Karcz, Konrad Wojciech
Poloczek, Jakub
Sawczyn, Tomasz
Dulska, Agnieszka
Kazura, Wojciech
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The main factor characteristic for low-grade systemic inflammation typical for obesity is oxidative stress (OS).
Reactive oxygen species (ROS) production is higher and more increased in time in the obese patients than in lean subjects.
Aims.
To assess the effect of ileal transposition (IT) and sham types of bariatric procedures on the antioxidative systems in the liver tissue of Zucker rats (Crl:ZUC Leprfa).
Method.
21 animals were divided into the experimental groups: control group (n=7), sham group (n=7), and IT group (n=7).
Sham and IT animals underwent selected surgery.
The concentration of total antioxidant capacity (TAC), total antioxidant status (TOS), and activity of glutathione reductase (glutathione-disulfide reductase, GR, GSR), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and total superoxide dismutase activity (SOD) were assessed in liver tissue 3 months after surgery.
Results.
IT procedure significantly increased TAC when compared to sham and the control group.
Animals after IT showed higher levels of TOS when compared to sham procedure.
The total amount of TOS was similar in IT and control groups.
GPx activity was increased in the groups submitted to the sham and IT surgery in relation to control.
GR and CAT activities were significantly higher after IT in comparison to control and sham procedures.
Total SOD and MnSOD were significantly higher in sham-operated animals in comparison to IT intervention and control groups.
Conclusions.
IT procedure had a positive impact on the diminishing of oxidative stress measured by TAC and TOS markers.
The dynamic, adaptive, and protective mechanisms of enzymatic antioxidant systems were observed after the IT but not sham procedure.
Nevertheless, 3 months after surgery, the midterm effect of bariatric surgery was observed, which might not fully balance the antioxidative response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Skrzep-Poloczek, Bronisława& Stygar, Dominika& Sawczyn, Tomasz& Romuk, Ewa& Chełmecka, Elżbieta& Poloczek, Jakub…[et al.]. 2018. Impact of Ileal Transposition Surgical Intervention on Antioxidant Status Measured in Liver Tissue of Obese Zucker Rats (Crl:ZUC-Leprfa). Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211969
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Skrzep-Poloczek, Bronisława…[et al.]. Impact of Ileal Transposition Surgical Intervention on Antioxidant Status Measured in Liver Tissue of Obese Zucker Rats (Crl:ZUC-Leprfa). Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1211969
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Skrzep-Poloczek, Bronisława& Stygar, Dominika& Sawczyn, Tomasz& Romuk, Ewa& Chełmecka, Elżbieta& Poloczek, Jakub…[et al.]. Impact of Ileal Transposition Surgical Intervention on Antioxidant Status Measured in Liver Tissue of Obese Zucker Rats (Crl:ZUC-Leprfa). Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1211969
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211969
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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