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Acute Hyperbaric Oxygenation, Contrary to Intermittent Hyperbaric Oxygenation, Adversely Affects Vasorelaxation in Healthy Sprague-Dawley Rats due to Increased Oxidative Stress
المؤلفون المشاركون
Cavka, Ana
Drenjancevic, Ines
Matić, Anita
Mihaljević, Zrinka
Barić, Lidija
Jukić, Ivana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-29
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The present study was aimed at assessing endothelium-dependent vasorelaxation, at measuring superoxide production in the aorta and femoral artery, and at determining antioxidative enzyme expression and activity in aortas of male Sprague-Dawley rats (N=135), randomized to an A-HBO2 group exposed to a single hyperbaric oxygenation session (120′ of 100% O2 at 2.0 bars), a 24H-HBO2 group (single session, examined 24 h after exposure), a 4D-HBO2 group (4 consecutive days of single sessions), and a CTRL group (untreated group).
Vasorelaxation of aortic rings in response to acetylcholine (AChIR) and to reduced pO2 (HIR) was tested in vitro in the absence/presence of NOS inhibitor L-NAME and superoxide scavenger TEMPOL.
eNOS, iNOS, antioxidative enzyme, and NADPH oxidase mRNA expression was assessed by qPCR.
Serum oxidative stress markers and enzyme activity were assessed by spectrometry, and superoxide production was determined by DHE fluorescence.
Impaired AChIR and HIR in the A-HBO2 group were restored by TEMPOL.
L-NAME inhibited AChIR in all groups.
Serum oxidative stress and superoxide production were increased in the A-HBO2 group compared to all other groups.
The mRNA expression of iNOS was decreased in the A-HBO2 and 24H-HBO2 groups while SOD1 and 3 and NADPH oxidase were increased in the 4D-HBO2 group.
The expression and activity of catalase and glutathione peroxidase were increased in the 4D-HBO2 group as well.
AChIR was NO dependent.
Acute HBO2 transiently impaired vasorelaxation due to increased oxidative stress.
Vasorelaxation was restored and oxidative stress was normalized 24 h after the treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mihaljević, Zrinka& Matić, Anita& Cavka, Ana& Barić, Lidija& Jukić, Ivana& Drenjancevic, Ines. 2018. Acute Hyperbaric Oxygenation, Contrary to Intermittent Hyperbaric Oxygenation, Adversely Affects Vasorelaxation in Healthy Sprague-Dawley Rats due to Increased Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211975
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mihaljević, Zrinka…[et al.]. Acute Hyperbaric Oxygenation, Contrary to Intermittent Hyperbaric Oxygenation, Adversely Affects Vasorelaxation in Healthy Sprague-Dawley Rats due to Increased Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1211975
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mihaljević, Zrinka& Matić, Anita& Cavka, Ana& Barić, Lidija& Jukić, Ivana& Drenjancevic, Ines. Acute Hyperbaric Oxygenation, Contrary to Intermittent Hyperbaric Oxygenation, Adversely Affects Vasorelaxation in Healthy Sprague-Dawley Rats due to Increased Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1211975
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1211975
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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