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Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities
المؤلفون المشاركون
Bonafè, Massimiliano
Gardini, Andrea C.
De Matteis, Serena
Giudetti, Anna M.
Ragusa, Andrea
Marisi, Giorgia
De Domenico, Stefania
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-04
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly malignant, recurrent, drug-resistant, and often diagnosed in the advanced stage.
It is clear that early diagnosis and a better understanding of molecular mechanisms contributing to HCC progression is clinically urgent.
Metabolic alterations clearly characterize HCC tumors.
Numerous clinical parameters currently used to assess liver functions reflect changes in both enzyme activity and metabolites.
Indeed, differences in glucose and acetate utilization are used as a valid clinical tool for stratifying patients with HCC.
Moreover, increased serum lactate can distinguish HCC from normal subjects, and serum lactate dehydrogenase is used as a prognostic indicator for HCC patients under therapy.
Currently, the emerging field of metabolomics that allows metabolite analysis in biological fluids is a powerful method for discovering new biomarkers.
Several metabolic targets have been identified by metabolomics approaches, and these could be used as biomarkers in HCC.
Moreover, the integration of different omics approaches could provide useful information on the metabolic pathways at the systems level.
In this review, we provided an overview of the metabolic characteristics of HCC considering also the reciprocal influences between the metabolism of cancer cells and their microenvironment.
Moreover, we also highlighted the interaction between hepatic metabolite production and their serum revelations through metabolomics researches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Matteis, Serena& Ragusa, Andrea& Marisi, Giorgia& De Domenico, Stefania& Gardini, Andrea C.& Bonafè, Massimiliano…[et al.]. 2018. Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212010
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Matteis, Serena…[et al.]. Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1212010
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Matteis, Serena& Ragusa, Andrea& Marisi, Giorgia& De Domenico, Stefania& Gardini, Andrea C.& Bonafè, Massimiliano…[et al.]. Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212010
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212010
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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