![](/images/graphics-bg.png)
Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis
المؤلفون المشاركون
Dua, Kamal
Shastri, Madhur D.
Shukla, Shakti Dhar
Eri, Rajaraman
Chong, Wai Chin
Peterson, Gregory M.
Patel, Rahul P.
O’Toole, Ronan F.
Hansbro, Philip M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, is the leading cause of mortality worldwide due to a single infectious agent.
The pathogen spreads primarily via aerosols and especially infects the alveolar macrophages in the lungs.
The lung has evolved various biological mechanisms, including oxidative stress (OS) responses, to counteract TB infection.
M.
tuberculosis infection triggers the generation of reactive oxygen species by host phagocytic cells (primarily macrophages).
The development of resistance to commonly prescribed antibiotics poses a challenge to treat TB; this commonly manifests as multidrug resistant tuberculosis (MDR-TB).
OS and antioxidant defense mechanisms play key roles during TB infection and treatment.
For instance, several established first-/second-line antitubercle antibiotics are administered in an inactive form and subsequently transformed into their active form by components of the OS responses of both host (nitric oxide, S-oxidation) and pathogen (catalase/peroxidase enzyme, EthA).
Additionally, M.
tuberculosis has developed mechanisms to survive high OS burden in the host, including the increased bacterial NADH/NAD+ ratio and enhanced intracellular survival (Eis) protein, peroxiredoxin, superoxide dismutases, and catalases.
Here, we review the interplay between lung OS and its effects on both activation of antitubercle antibiotics and the strategies employed by M.
tuberculosis that are essential for survival of both drug-susceptible and drug-resistant bacterial subtypes.
We then outline potential new therapies that are based on combining standard antitubercular antibiotics with adjuvant agents that could limit the ability of M.
tuberculosis to counter the host’s OS response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shastri, Madhur D.& Shukla, Shakti Dhar& Chong, Wai Chin& Dua, Kamal& Peterson, Gregory M.& Patel, Rahul P.…[et al.]. 2018. Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212078
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shastri, Madhur D.…[et al.]. Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212078
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shastri, Madhur D.& Shukla, Shakti Dhar& Chong, Wai Chin& Dua, Kamal& Peterson, Gregory M.& Patel, Rahul P.…[et al.]. Role of Oxidative Stress in the Pathology and Management of Human Tuberculosis. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212078
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212078
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)