Hippocampal Dysfunction Provoked by Mercury Chloride Exposure: Evaluation of Cognitive Impairment, Oxidative Stress, Tissue Injury and Nature of Cell Death
المؤلفون المشاركون
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
Lima, Rafael Rodrigues
Crespo-López, Maria Elena
Fernandes, Rafael M.
Fagundes, Nathalia Carolina Fernandes
de Oliveira, Edivaldo Herculano Correa
Aragão, Walessa Alana Bragança
Silva, Marcia Cristina Freitas
Teixeira, Francisco Bruno
Amado, Lilian Lund
Sagica, Fernanda Espírito Santo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-10
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Mercury (Hg) is a highly toxic metal, which can be found in its inorganic form in the environment.
This form presents lower liposolubility and lower absorption in the body.
In order to elucidate the possible toxicity of inorganic Hg in the hippocampus, we investigated the potential of low doses of mercury chloride (HgCl2) to promote hippocampal dysfunction by employing a chronic exposure model.
For this, 56 rats were exposed to HgCl2 (0.375 mg/kg/day) via the oral route for 45 days.
After the exposure period, the animals were submitted to the cognitive test of fear memory.
The hippocampus was collected for the measurement of total Hg levels, analysis of oxidative stress, and evaluation of cytotoxicity, apoptosis, and tissue injury.
It was observed that chronic exposure to inorganic Hg promotes an increase in mercury levels in this region and damage to short- and long-term memory.
Furthermore, we found that this exposure model provoked oxidative stress, which led to cytotoxicity and cell death by apoptosis, affecting astrocytes and neurons in the hippocampus.
Our study demonstrated that inorganic Hg, even with its low liposolubility, is able to produce deleterious effects in the central nervous system, resulting in cognitive impairment and hippocampal damage when administered for a long time at low doses in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aragão, Walessa Alana Bragança& Teixeira, Francisco Bruno& Fagundes, Nathalia Carolina Fernandes& Fernandes, Rafael M.& Fernandes, Luanna Melo Pereira& Silva, Marcia Cristina Freitas…[et al.]. 2018. Hippocampal Dysfunction Provoked by Mercury Chloride Exposure: Evaluation of Cognitive Impairment, Oxidative Stress, Tissue Injury and Nature of Cell Death. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212112
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aragão, Walessa Alana Bragança…[et al.]. Hippocampal Dysfunction Provoked by Mercury Chloride Exposure: Evaluation of Cognitive Impairment, Oxidative Stress, Tissue Injury and Nature of Cell Death. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1212112
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aragão, Walessa Alana Bragança& Teixeira, Francisco Bruno& Fagundes, Nathalia Carolina Fernandes& Fernandes, Rafael M.& Fernandes, Luanna Melo Pereira& Silva, Marcia Cristina Freitas…[et al.]. Hippocampal Dysfunction Provoked by Mercury Chloride Exposure: Evaluation of Cognitive Impairment, Oxidative Stress, Tissue Injury and Nature of Cell Death. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212112
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212112
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر