Computational Studies Applied to Flavonoids against Alzheimer’s and Parkinson’s Diseases
المؤلفون المشاركون
Mendonça Junior, F. J. B.
Ernestine, Nkwengoua
Scotti, Luciana
Scotti, Marcus Tullius
Monteiro, Alex France M.
Viana, Jéssika De O.
Nayarisseri, Anuraj
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-30
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
Neurodegenerative diseases, such as Parkinson’s and Alzheimer’s, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms.
Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases.
The present article reports on in silico enzymatic target studies and natural products as inhibitors for the treatment of Parkinson’s and Alzheimer’s diseases.
In this study we evaluated 39 flavonoids using prediction of molecular properties and in silico docking studies, while comparing against 7 standard reference compounds: 4 for Parkinson’s and 3 for Alzheimer’s.
Osiris analysis revealed that most of the flavonoids presented no toxicity and good absorption parameters.
The Parkinson’s docking results using selected flavonoids as compared to the standards with four proteins revealed similar binding energies, indicating that the compounds 8-prenylnaringenin, europinidin, epicatechin gallate, homoeriodictyol, capensinidin, and rosinidin are potential leads with the necessary pharmacological and structural properties to be drug candidates.
The Alzheimer’s docking results suggested that seven of the 39 flavonoids studied, being those with the best molecular docking results, presenting no toxicity risks, and having good absorption rates (8-prenylnaringenin, europinidin, epicatechin gallate, homoeriodictyol, aspalathin, butin, and norartocarpetin) for the targets analyzed, are the flavonoids which possess the most adequate pharmacological profiles.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Monteiro, Alex France M.& Viana, Jéssika De O.& Nayarisseri, Anuraj& Ernestine, Nkwengoua& Mendonça Junior, F. J. B.& Scotti, Marcus Tullius…[et al.]. 2018. Computational Studies Applied to Flavonoids against Alzheimer’s and Parkinson’s Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1212127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Monteiro, Alex France M.…[et al.]. Computational Studies Applied to Flavonoids against Alzheimer’s and Parkinson’s Diseases. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-21.
https://search.emarefa.net/detail/BIM-1212127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Monteiro, Alex France M.& Viana, Jéssika De O.& Nayarisseri, Anuraj& Ernestine, Nkwengoua& Mendonça Junior, F. J. B.& Scotti, Marcus Tullius…[et al.]. Computational Studies Applied to Flavonoids against Alzheimer’s and Parkinson’s Diseases. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1212127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر