Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats
المؤلفون المشاركون
Abdelazim, Aaser M.
Abdelrazek, Heba M. A.
Tag, Hend M.
Kilany, Omnia E.
Muhammad, Muhammad A. A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diabetes mellitus is one of the metabolic diseases having several complications.
Nigella sativa oil (NSO) might have beneficial effects in the treatment of diabetic complications.
Thirty-two mature male Wistar rats were equally divided into four experimental groups: control, control NSO 2 mL/kg, streptozotocin- (STZ-) induced diabetic, and diabetic (STZ-induced) treated with oral NSO 2 mg/kg for 30 days.
Fasting blood glucose (FBG), insulin, and lipid profile levels were determined.
Pancreatic and hepatic tissues were used for catalase and GSH.
Histopathology, hepatic glycogen contents, insulin immunohistochemistry, and pancreatic islet morphometry were performed.
NSO 2 mL/kg was noticed to decrease (P<0.05) FBG and increase (P<0.05) insulin levels in diabetic rats than in diabetic nontreated animals.
Lipid profile showed significant (P<0.5) improvement in diabetic rats that received NSO 2 mL/kg than in the diabetic group.
Both pancreatic and hepatic catalase and GSH activities revealed a significant (P<0.05) increment in the diabetic group treated with NSO than in the diabetic animals.
NSO improved the histopathological picture and hepatic glycogen contents of the diabetic group as well as increased (P<0.05) insulin immunoreactive parts % and mean pancreatic islet diameter.
NSO exerts ameliorative and therapeutic effects on the STZ-induced diabetic male Wistar rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abdelrazek, Heba M. A.& Kilany, Omnia E.& Muhammad, Muhammad A. A.& Tag, Hend M.& Abdelazim, Aaser M.. 2018. Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abdelrazek, Heba M. A.…[et al.]. Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abdelrazek, Heba M. A.& Kilany, Omnia E.& Muhammad, Muhammad A. A.& Tag, Hend M.& Abdelazim, Aaser M.. Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر