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Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1
المؤلفون المشاركون
Monteiro, Marta Chagas
dos Santos, Savio M.
Romeiro, Camila Fernanda Rodrigues
Rodrigues, Caroline Azulay
Gomes, Bruno Alexandre Quadros
Silva, João Paulo Bastos
Gonçalves, Pricila Rodrigues
Sakai, Joni Tetsuo
Mendes, Paulo Fernando Santos
Varela, Everton Luiz Pompeu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-30
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease (AD) is a progressive and neurodegenerative disorder of the cortex and hippocampus, which eventually leads to cognitive impairment.
Although the etiology of AD remains unclear, the presence of β-amyloid (Aβ) peptides in these learning and memory regions is a hallmark of AD.
Therefore, the inhibition of Aβ peptide aggregation has been considered the primary therapeutic strategy for AD treatment.
Many studies have shown that resveratrol has antioxidant, anti-inflammatory, and neuroprotective properties and can decrease the toxicity and aggregation of Aβ peptides in the hippocampus of AD patients, promote neurogenesis, and prevent hippocampal damage.
In addition, the antioxidant activity of resveratrol plays an important role in neuronal differentiation through the activation of silent information regulator-1 (SIRT1).
SIRT1 plays a vital role in the growth and differentiation of neurons and prevents the apoptotic death of these neurons by deacetylating and repressing p53 activity; however, the exact mechanisms remain unclear.
Resveratrol also has anti-inflammatory effects as it suppresses M1 microglia activation, which is involved in the initiation of neurodegeneration, and promotes Th2 responses by increasing anti-inflammatory cytokines and SIRT1 expression.
This review will focus on the antioxidant and anti-inflammatory neuroprotective effects of resveratrol, specifically on its role in SIRT1 and the association with AD pathophysiology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gomes, Bruno Alexandre Quadros& Silva, João Paulo Bastos& Romeiro, Camila Fernanda Rodrigues& dos Santos, Savio M.& Rodrigues, Caroline Azulay& Gonçalves, Pricila Rodrigues…[et al.]. 2018. Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gomes, Bruno Alexandre Quadros…[et al.]. Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1212159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gomes, Bruno Alexandre Quadros& Silva, João Paulo Bastos& Romeiro, Camila Fernanda Rodrigues& dos Santos, Savio M.& Rodrigues, Caroline Azulay& Gonçalves, Pricila Rodrigues…[et al.]. Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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