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Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2HO-1 Defense Pathway
المؤلفون المشاركون
Barakat, Bassant M.
Ahmed, Hebatalla I.
Bahr, Hoda I.
Elbahaie, Alaaeldeen M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The current study aimed to investigate the potential protective role of boswellic acids (BAs) against doxorubicin- (DOX-) induced hepatotoxicity.
Also, the possible mechanisms underlying this protection; antioxidant, as well as the modulatory effect on the Nrf2 transcription factor/hem oxygenase-1 (Nrf2/HO-1) pathway in liver tissues, was investigated.
Animals were allocated to five groups: group 1: the saline control, group 2: the DOX group, animals received DOX (6 mg/kg, i.p.) weekly for a period of three weeks, and groups 3–5: animals received DOX (6 mg/kg, i.p.) weekly and received protective doses of BAs (125, 250, and 500 mg/kg/day).
Treatment with BAs significantly improved the altered liver enzyme activities and oxidative stress markers.
This was coupled with significant improvement in liver histopathological features.
BAs increased the Nrf2 and HO-1 expression, which provided protection against DOX-induced oxidative insult.
The present results demonstrated that BAs appear to scavenge ROS and inhibit lipid peroxidation and DNA damage of DOX-induced hepatotoxicity.
The antioxidant efficacy of BAs might arise from its modulation of the Nrf2/HO-1 pathway and thereby protected liver from DOX-induced oxidative injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barakat, Bassant M.& Ahmed, Hebatalla I.& Bahr, Hoda I.& Elbahaie, Alaaeldeen M.. 2018. Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2HO-1 Defense Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212194
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barakat, Bassant M.…[et al.]. Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2HO-1 Defense Pathway. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212194
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barakat, Bassant M.& Ahmed, Hebatalla I.& Bahr, Hoda I.& Elbahaie, Alaaeldeen M.. Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2HO-1 Defense Pathway. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212194
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212194
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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