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p-Coumaric Acid Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by MAPK Signaling
المؤلفون المشاركون
Xiao, Hai-tao
Peng, Jiao
Zheng, Ting-ting
Liang, Yue
Duan, Li-fang
Zhang, Yao-dong
Wang, Li-Jun
He, Guang-ming
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
To protect against oxidative stress-induced apoptosis in lens epithelial cells is a potential strategy in preventing cataract formation.
The present study aimed at studying the protective effect and underlying mechanisms of p-coumaric acid (p-CA) on hydrogen peroxide- (H2O2-) induced apoptosis in human lens epithelial (HLE) cells (SRA 01–04).
Cells were pretreated with p-CA at a concentration of 3, 10, and 30 μM before the treatment of H2O2 (275 μM).
Results showed that pretreatment with p-CA significantly protected against H2O2-induced cell death in a dose-dependent manner, as well as downregulating the expressions of both cleaved caspase-3 and cleaved caspase-9 in HLE cells.
Moreover, p-CA also greatly suppressed H2O2-induced intracellular ROS production and mitochondrial membrane potential loss and elevated the activities of T-SOD, CAT, and GSH-Px of H2O2-treated cells.
As well, in vitro study showed that p-CA also suppressed H2O2-induced phosphorylation of p-38, ERK, and JNK in HLE cells.
These findings demonstrate that p-CA suppresses H2O2-induced HLE cell apoptosis through modulating MAPK signaling pathways and suggest that p-CA has a potential therapeutic role in the prevention of cataract.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peng, Jiao& Zheng, Ting-ting& Liang, Yue& Duan, Li-fang& Zhang, Yao-dong& Wang, Li-Jun…[et al.]. 2018. p-Coumaric Acid Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by MAPK Signaling. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212264
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peng, Jiao…[et al.]. p-Coumaric Acid Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by MAPK Signaling. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212264
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peng, Jiao& Zheng, Ting-ting& Liang, Yue& Duan, Li-fang& Zhang, Yao-dong& Wang, Li-Jun…[et al.]. p-Coumaric Acid Protects Human Lens Epithelial Cells against Oxidative Stress-Induced Apoptosis by MAPK Signaling. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212264
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212264
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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