ROS-Induced DNA Damage Associates with Abundance of Mitochondrial DNA in White Blood Cells of the Untreated Schizophrenic Patients
المؤلفون المشاركون
Izevskaya, Vera L.
Kostyuk, Svetlana
Ershova, Elizaveta
Veiko, Natalia
Kutsev, S. I.
Jestkova, E. M.
Kostyuk, G. P.
Lezheiko, Tatyana V.
Golimbet, Vera E.
Dolgikh, Olga A.
Chestkov, I. V.
Kolesina, N. Yu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this study was (1) to examine the leukocyte mtDNA copy number (CN) in unmedicated (SZ (m−)) and medicated (SZ (m+)) male patients with paranoid schizophrenia (SZ) in comparison with the healthy male controls (HC) and (2) to compare the leukocyte mtDNA CN with the content of an oxidation marker 8-oxodG in lymphocytes of the SZ (m−) patients.
Methods.
We evaluated leukocyte mtDNA CN of 110 subjects with SZ in comparison with 60 male HC by the method qPCR (ratio mtDNA/nDNA (gene B2M) was detected).
SZ patients were divided into two subgroups.
The patients of the subgroups SZ (m+) (N=55) were treated with standard antipsychotic medications in the hospital.
The patients of the subgroup SZ (m−) (N=55) were not treated before venous blood was sampled.
To evaluate oxidative DNA damage, we quantified the levels of 8-oxodG in lymphocytes (flow cytometry) of SZ (m−) patients (N=55) and HC (N=30).
Results.
The leukocyte mtDNA CN showed no significant difference in SZ (m+) patients and HC.
The mtDNA CN in the unmedicated subgroup SZ (m−) was significantly higher than that in the SZ (m+) subgroup or in HC group.
The level of 8-oxodG in the subgroup SZ (m−) was significantly higher than that in HC group.
Conclusion.
The leukocytes of the unmedicated SZ male patients with acute psychosis contain more mtDNA than the leukocytes of the male SZ patients treated with antipsychotic medications or the healthy controls.
MtDNA content positively correlates with the level of 8-oxodG in the unmedicated SZ patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chestkov, I. V.& Jestkova, E. M.& Ershova, Elizaveta& Golimbet, Vera E.& Lezheiko, Tatyana V.& Kolesina, N. Yu…[et al.]. 2018. ROS-Induced DNA Damage Associates with Abundance of Mitochondrial DNA in White Blood Cells of the Untreated Schizophrenic Patients. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212273
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chestkov, I. V.…[et al.]. ROS-Induced DNA Damage Associates with Abundance of Mitochondrial DNA in White Blood Cells of the Untreated Schizophrenic Patients. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212273
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chestkov, I. V.& Jestkova, E. M.& Ershova, Elizaveta& Golimbet, Vera E.& Lezheiko, Tatyana V.& Kolesina, N. Yu…[et al.]. ROS-Induced DNA Damage Associates with Abundance of Mitochondrial DNA in White Blood Cells of the Untreated Schizophrenic Patients. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212273
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212273
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر