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Upregulation of Heme Oxygenase-1 by Hemin Alleviates Sepsis-Induced Muscle Wasting in Mice
المؤلفون المشاركون
Bo, Lulong
Deng, Xiaoming
Sui, Da-ming
Bian, Jinjun
Yu, Xiongwei
Han, Wenjun
Wang, Changli
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hemin, an inducer of heme oxygenase-1 (HO-1), can enhance the activation of HO-1.
HO-1 exhibits a variety of activities, such as anti-inflammatory, antioxidative, and antiapoptotic functions.
The objective of this study was to investigate the effects of hemin on sepsis-induced skeletal muscle wasting and to explore the mechanisms by which hemin exerts its effects.
Cecal ligation and perforation (CLP) was performed to create a sepsis mouse model.
Mice were randomly divided into four groups: control, CLP, CLP plus group, and CLP-hemin-ZnPP (a HO-1 inhibitor).
The weight of the solei from the mice was measured, and histopathology was examined.
Cytokines were measured by enzyme-linked immunosorbent assay (ELISA).
Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blotting were used to assess the expression levels of HO-1 and atrogin-1.
Furthermore, we investigated the antioxidative effects of HO-1 by detecting malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity.
CLP led to dramatic skeletal muscle weakness and atrophy, but pretreatment with hemin protected mice against CLP-mediated muscle atrophy.
Hemin also induced high HO-1 expression, which resulted in suppressed proinflammatory cytokine and reactive oxygen species (ROS) production.
The expression of MuRF1 and atrogin-1, two ubiquitin ligases of the ubiquitin-proteasome system- (UPS-) mediated proteolysis, was also inhibited by increased HO-1 levels.
Hemin-mediated increases in HO-1 expression exert protective effects on sepsis-induced skeletal muscle atrophy at least partly by inhibiting the expression of proinflammatory cytokines, UPS-mediated proteolysis, and ROS activation.
Therefore, hemin might be a new treatment target against sepsis-induced skeletal muscle atrophy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Xiongwei& Han, Wenjun& Wang, Changli& Sui, Da-ming& Bian, Jinjun& Bo, Lulong…[et al.]. 2018. Upregulation of Heme Oxygenase-1 by Hemin Alleviates Sepsis-Induced Muscle Wasting in Mice. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212312
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Xiongwei…[et al.]. Upregulation of Heme Oxygenase-1 by Hemin Alleviates Sepsis-Induced Muscle Wasting in Mice. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212312
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Xiongwei& Han, Wenjun& Wang, Changli& Sui, Da-ming& Bian, Jinjun& Bo, Lulong…[et al.]. Upregulation of Heme Oxygenase-1 by Hemin Alleviates Sepsis-Induced Muscle Wasting in Mice. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212312
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212312
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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