Effect of Alkaloid Extract from African Jointfir (Gnetum africanum) Leaves on Manganese-Induced Toxicity in Drosophila melanogaster
المؤلفون المشاركون
Oboh, Ganiyu
Ogunsuyi, Opeyemi Babatunde
Awonyemi, Olatunde Isaac
Atoki, Victor Ayomide
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Metal-induced toxicity in fruit fly (Drosophila melanogaster) is one of the established models for studying neurotoxicity and neurodegenerative diseases.
Phytochemicals, especially alkaloids, have been reported to exhibit neuroprotection.
Here, we assessed the protective effect of alkaloid extract from African Jointfir (Gnetum africanum) leaf on manganese- (Mn-) induced toxicity in wild type fruit fly.
Flies were exposed to 10 mM Mn, the alkaloid extract and cotreatment of Mn plus extract, respectively.
The survival rate and locomotor performance of the flies were assessed 5 days posttreatment, at which point the flies were homogenized and assayed for acetylcholinesterase (AChE) activity, nitric oxide (NO), and reactive oxygen species (ROS) levels.
Results showed that the extract significantly reverted Mn-induced reduction in the survival rate and locomotor performance of the flies.
Furthermore, the extract counteracted the Mn-induced elevation in AChE activity, NO, and ROS levels.
The alkaloid extract of the African Jointfir leaf may hence be a source of useful phytochemicals for the development of novel therapies for the management of neurodegeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oboh, Ganiyu& Ogunsuyi, Opeyemi Babatunde& Awonyemi, Olatunde Isaac& Atoki, Victor Ayomide. 2018. Effect of Alkaloid Extract from African Jointfir (Gnetum africanum) Leaves on Manganese-Induced Toxicity in Drosophila melanogaster. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212324
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oboh, Ganiyu…[et al.]. Effect of Alkaloid Extract from African Jointfir (Gnetum africanum) Leaves on Manganese-Induced Toxicity in Drosophila melanogaster. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212324
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oboh, Ganiyu& Ogunsuyi, Opeyemi Babatunde& Awonyemi, Olatunde Isaac& Atoki, Victor Ayomide. Effect of Alkaloid Extract from African Jointfir (Gnetum africanum) Leaves on Manganese-Induced Toxicity in Drosophila melanogaster. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212324
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212324
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر