Enhanced Oxidative Damage and Nrf2 Downregulation Contribute to the Aggravation of Periodontitis by Diabetes Mellitus
المؤلفون المشاركون
Mao, Yixin
Li, Xumin
Huang, Shengbin
Wu, Gang
Gan, Xueqi
Shi, L. X.
Sun, Xiaoyu
Zhang, Xiaorong
Ji, Yinghui
Cai, Wenjin
Wang, Panpan
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-12-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetes mellitus is a well-recognized risk factor for periodontitis.
The goal of the present study was to elucidate whether oxidative stress and nuclear factor erythroid 2-related factor 2 (Nrf2) participate in the aggravation of periodontitis by diabetes.
For this purpose, we assigned Wistar rats to control, periodontitis, diabetes, and diabetic periodontitis groups.
Two weeks after induction of diabetes by streptozotocin, periodontitis was induced by ligation.
Two weeks later, periodontal tissues and blood were harvested and analyzed by stereomicroscopy, immunohistochemistry, and real-time polymerase chain reaction.
We found that ligation induced more severe bone loss and periodontal cell apoptosis in diabetic rats than in normal rats (p<0.05).
Compared with the control group, periodontitis significantly enhanced local oxidative damage (elevated expression of 3-nitrotyrosine, 4-hydroxy-2-nonenal, and 8-hydroxy-deoxyguanosine), whereas diabetes significantly increased systemic oxidative damage and suppressed antioxidant capacity (increased malondialdehyde expression and decreased superoxide dismutase activity) (p<0.05).
Simultaneous periodontitis and diabetes synergistically aggravated both local and systemic oxidative damage (p<0.05); this finding was strongly correlated with the more severe periodontal destruction in diabetic periodontitis.
Furthermore, gene and protein expression of Nrf2 was significantly downregulated in diabetic periodontitis (p<0.05).
Multiple regression analysis indicated that the reduced Nrf2 expression was strongly correlated with the aggravated periodontal destruction and oxidative damage in diabetic periodontitis.
We conclude that enhanced local and systemic oxidative damage and Nrf2 downregulation contribute to the development and progression of diabetic periodontitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xumin& Sun, Xiaoyu& Zhang, Xiaorong& Mao, Yixin& Ji, Yinghui& Shi, L. X.…[et al.]. 2018. Enhanced Oxidative Damage and Nrf2 Downregulation Contribute to the Aggravation of Periodontitis by Diabetes Mellitus. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212382
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xumin…[et al.]. Enhanced Oxidative Damage and Nrf2 Downregulation Contribute to the Aggravation of Periodontitis by Diabetes Mellitus. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1212382
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xumin& Sun, Xiaoyu& Zhang, Xiaorong& Mao, Yixin& Ji, Yinghui& Shi, L. X.…[et al.]. Enhanced Oxidative Damage and Nrf2 Downregulation Contribute to the Aggravation of Periodontitis by Diabetes Mellitus. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212382
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1212382
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر